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- W2054404772 abstract "In Alzheimer's disease brain, imbalance of cholesterol usually attends by neurofibrillary tangles (NFTs), which mainly consist of hyperphosphorylated tau. Some researchers reported that cholesterol overload colocalized with NFTs. Others alleged that the reduction of cholesterol caused tau hyperphosphorylation. It shows the relationship between cholesterol and tau phosphorylation is still not clear. The present study investigated different level of cholesterol in cerebrospinal fluid (CSF) on tau phosphorylation. We carried out Morris water maze to test the rats' memory deficit 24 h after 2, 8, 20 μg/ ml of cholesterol was delivered into lateral ventricles via stereotactic brain injection respectively. Tau hyperphosphorylation and distribution were assayed by immunohistochemistry using sites specific antibodies (pS 396, Tau-1 and total tau antibody R134d). 24 hours post-injection, AD-like spatial memory retention disturbance was observed in 2, 20 μg/ ml of cholesterol rats, but not in 8 μg/ ml of cholesterol rats. Meanwhile, immunohistochemistry staining showed that the immunoreaction of tau at pS 396 epitope was enhanced, and the reaction at Tau-1 epitope was weakened significantly at 24 h after injection of 2, 20 μg/ ml of cholesterol, suggesting hyperphosphorylation of tau at Ser396 (pS 396) and Ser199/Ser202 (Tau-1) sites, while 8μg/ ml of cholesterol didn't alter tau phosphorylation. Either high or low level of cholesterol all can induce tau hyperphosphorylation, thus result in the memory deficits." @default.
- W2054404772 created "2016-06-24" @default.
- W2054404772 creator A5026024648 @default.
- W2054404772 date "2010-07-01" @default.
- W2054404772 modified "2023-10-12" @default.
- W2054404772 title "P1-356: Effect of cholesterol in CSF on tau phosphorylation" @default.
- W2054404772 doi "https://doi.org/10.1016/j.jalz.2010.05.910" @default.
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