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- W2054405069 abstract "Most researchers agree that idiopathic scoliosis (IS) is a multifactorial disease influenced by complex genetic and environmental factors. The onset of the spinal deformity that determines the natural course of the disease, usually occurs in the juvenile or adolescent period. Transforming growth factors β (TGF- β s) and their receptors, TGFBRs, may be considered as candidate genes related to IS susceptibility and natural history. This study explores the transcriptional profile of TGF- β s, TGFBRs, and TGF- β responsive genes in the paravertebral muscles of patients with juvenile and adolescent idiopathic scoliosis (JIS and AIS, resp.). Muscle specimens were harvested intraoperatively and grouped according to the side of the curve and the age of scoliosis onset. The results of microarray and qRT-PCR analysis confirmed significantly higher transcript abundances of TGF- β 2, TGF- β 3, and TGFBR2 in samples from the curve concavity of AIS patients, suggesting a difference in TGF- β signaling in the pathogenesis of juvenile and adolescent curves. Analysis of TGF- β responsive genes in the transcriptomes of patients with AIS suggested overrepresentation of the genes localized in the extracellular region of curve concavity: LTBP3, LTBP4, ITGB4, and ITGB5. This finding suggests the extracellular region of paravertebral muscles as an interesting target for future molecular research into AIS pathogenesis." @default.
- W2054405069 created "2016-06-24" @default.
- W2054405069 creator A5011462746 @default.
- W2054405069 creator A5013791190 @default.
- W2054405069 creator A5015831889 @default.
- W2054405069 creator A5042293885 @default.
- W2054405069 date "2014-01-01" @default.
- W2054405069 modified "2023-09-26" @default.
- W2054405069 title "Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis" @default.
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- W2054405069 doi "https://doi.org/10.1155/2014/594287" @default.
- W2054405069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4181945" @default.
- W2054405069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25313366" @default.
- W2054405069 hasPublicationYear "2014" @default.
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