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- W2054406032 abstract "Thrombotic thrombocytopenic purpura (TTP) is a rare but severe disorder characterized by hemolytic anemia, thrombocytopenia, fever, renal failure, and neurologic manifestations. Plasma exchange is the most effective treatment for this condition reducing mortality from 90% in untreated patients to 10%. However, infections acquired during the course of therapy could lead to early relapse of TTP. In this case report, we report three patients with TTP who initially responded well to plasma exchange treatments but suffered early relapses following bacterial infections. All these patients achieved remission once appropriate antibiotic therapy was instituted although one patient eventually received four courses of rituximab. This report emphasizes the need to be vigilant for new infections especially urinary tract infections in TTP patients undergoing plasma exchange. Instituting appropriate antibiotic therapy once an infection is suspected may reduce the need for prolonged plasma exchange procedures and extended hospital stay." @default.
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- W2054406032 date "2007-01-01" @default.
- W2054406032 modified "2023-10-02" @default.
- W2054406032 title "Infection as a cause of early relapse in patients recovering from thrombotic thrombocytopenic purpura" @default.
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- W2054406032 doi "https://doi.org/10.1002/jca.20119" @default.
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