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- W2054406517 endingPage "437" @default.
- W2054406517 startingPage "424" @default.
- W2054406517 abstract "Reversible phosphorylation, tightly controlled by protein kinases and phosphatases, plays a central role in mediating biological processes, such as protein–protein interactions, subcellular translocation, and activation of cellular enzymes. MS ‐based phosphoproteomics has now allowed the detection and quantification of tens of thousands of phosphorylation sites from a typical biological sample in a single experiment, which has posed new challenges in functional analysis of each and every phosphorylation site on specific signaling phosphoproteins of interest. In this article, we review recent advances in the functional analysis of targeted phosphorylation carried out by various chemical and biological approaches in combination with the MS ‐based phosphoproteomics. This review focuses on three types of strategies, including forward functional analysis, defined for the result‐driven phosphoproteomics efforts in determining the substrates of a specific protein kinase; reverse functional analysis, defined for tracking the kinase(s) for specific phosphosite(s) derived from the discovery‐driven phosphoproteomics efforts; and MS ‐based analysis on the structure–function relationship of phosphoproteins. It is expected that this review will provide a state‐of‐the‐art overview of functional analysis of site‐specific phosphorylation and explore new perspectives and outline future challenges." @default.
- W2054406517 created "2016-06-24" @default.
- W2054406517 creator A5002218939 @default.
- W2054406517 creator A5044990015 @default.
- W2054406517 date "2013-01-02" @default.
- W2054406517 modified "2023-09-30" @default.
- W2054406517 title "Integration of phosphoproteomic, chemical, and biological strategies for the functional analysis of targeted protein phosphorylation" @default.
- W2054406517 cites W1482513578 @default.
- W2054406517 cites W1489442306 @default.
- W2054406517 cites W1519730847 @default.
- W2054406517 cites W1538925875 @default.
- W2054406517 cites W1965296166 @default.
- W2054406517 cites W1966465056 @default.
- W2054406517 cites W1967235964 @default.
- W2054406517 cites W1969556563 @default.
- W2054406517 cites W1970990473 @default.
- W2054406517 cites W1973638188 @default.
- W2054406517 cites W1975024278 @default.
- W2054406517 cites W1975563654 @default.
- W2054406517 cites W1976990046 @default.
- W2054406517 cites W1978198117 @default.
- W2054406517 cites W1978494635 @default.
- W2054406517 cites W1979653069 @default.
- W2054406517 cites W1981198317 @default.
- W2054406517 cites W1982136041 @default.
- W2054406517 cites W1982375470 @default.
- W2054406517 cites W1983583299 @default.
- W2054406517 cites W1986228306 @default.
- W2054406517 cites W1989762353 @default.
- W2054406517 cites W1991989394 @default.
- W2054406517 cites W1993297445 @default.
- W2054406517 cites W1997785599 @default.
- W2054406517 cites W1999811798 @default.
- W2054406517 cites W2000299127 @default.
- W2054406517 cites W2010156609 @default.
- W2054406517 cites W2010161321 @default.
- W2054406517 cites W2010516785 @default.
- W2054406517 cites W2010709196 @default.
- W2054406517 cites W2011734992 @default.
- W2054406517 cites W2012362589 @default.
- W2054406517 cites W2017410716 @default.
- W2054406517 cites W2017679390 @default.
- W2054406517 cites W2018078143 @default.
- W2054406517 cites W2020459598 @default.
- W2054406517 cites W2021961486 @default.
- W2054406517 cites W2023389323 @default.
- W2054406517 cites W2026507477 @default.
- W2054406517 cites W2027980594 @default.
- W2054406517 cites W2028387937 @default.
- W2054406517 cites W2031028006 @default.
- W2054406517 cites W2033411979 @default.
- W2054406517 cites W2033432423 @default.
- W2054406517 cites W2035317981 @default.
- W2054406517 cites W2037367203 @default.
- W2054406517 cites W2041600623 @default.
- W2054406517 cites W2043581879 @default.
- W2054406517 cites W2043696829 @default.
- W2054406517 cites W2045856882 @default.
- W2054406517 cites W2048352536 @default.
- W2054406517 cites W2051274533 @default.
- W2054406517 cites W2054538338 @default.
- W2054406517 cites W2054587674 @default.
- W2054406517 cites W2055519466 @default.
- W2054406517 cites W2055901277 @default.
- W2054406517 cites W2057657722 @default.
- W2054406517 cites W2058366363 @default.
- W2054406517 cites W2062656880 @default.
- W2054406517 cites W2063013228 @default.
- W2054406517 cites W2066923254 @default.
- W2054406517 cites W2068578318 @default.
- W2054406517 cites W2071437006 @default.
- W2054406517 cites W2072389876 @default.
- W2054406517 cites W2073879910 @default.
- W2054406517 cites W2078793318 @default.
- W2054406517 cites W2079568341 @default.
- W2054406517 cites W2080141037 @default.
- W2054406517 cites W2084152182 @default.
- W2054406517 cites W2084929233 @default.
- W2054406517 cites W2086405779 @default.
- W2054406517 cites W2088148959 @default.
- W2054406517 cites W2089033458 @default.
- W2054406517 cites W2091787667 @default.
- W2054406517 cites W2096286606 @default.
- W2054406517 cites W2098930497 @default.
- W2054406517 cites W2101859467 @default.
- W2054406517 cites W2102247469 @default.
- W2054406517 cites W2103479321 @default.
- W2054406517 cites W2104726963 @default.
- W2054406517 cites W2105793503 @default.
- W2054406517 cites W2106647330 @default.
- W2054406517 cites W2107835389 @default.
- W2054406517 cites W2108357729 @default.
- W2054406517 cites W2109125373 @default.
- W2054406517 cites W2114312604 @default.
- W2054406517 cites W2115509391 @default.
- W2054406517 cites W2117629868 @default.
- W2054406517 cites W2125197632 @default.
- W2054406517 cites W2125947965 @default.