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- W2054406938 abstract "Dose-rate effects on chromosome aberrations in the low-dose-rate range have not been evaluated previously. The incidences of chromosome aberrations were analysed in splenic lymphocytes from female specific pathogen-free (SPF) C3H mice that were continuously irradiated with low- or medium-dose-rate (LDR, MDR) (137)Cs γ rays from 56 days of age to evaluate the dose-rate effects. The dose-response relationship for the frequency of dicentric chromosome aberration at each dose rate (400 mGy/22h/day, 20 mGy/22h/day and 1 mGy/22h/day) was obtained using age-adjusted multiple linear regression analysis assuming that the relationship can be represented by a linear or linear quadratic model and a test for the difference between the irradiated group and the non-irradiated group. Values of the linear term, shown as the slope, decreased as the dose rate was reduced from 400 mGy/22h/day (18.2 mGy h(-1)) to 1 mGy/22h/day (0.045 mGy h(-1)), indicating a positive dose-rate effect in the dose-rate region. The incidences of dicentric chromosomes and translocation for LDR (20 mGy day(-1)) were compared with those for HDR (890 mGy min(-1)) irradiation at each total dose to obtain the dose and dose-rate effectiveness factor (DDREF). The DDREFs were 4.5 for dicentrics and 2.3 for translocations at a total dose of 100 mGy based on the chromosome aberration rate. These results will be useful for estimating the risk of LDR radiation exposure and radiation protection." @default.
- W2054406938 created "2016-06-24" @default.
- W2054406938 creator A5021465120 @default.
- W2054406938 creator A5039325102 @default.
- W2054406938 creator A5052483359 @default.
- W2054406938 date "2013-01-07" @default.
- W2054406938 modified "2023-09-23" @default.
- W2054406938 title "Dose-rate effects and dose and dose-rate effectiveness factor on frequencies of chromosome aberrations in splenic lymphocytes from mice continuously exposed to low-dose-rate gamma-radiation" @default.
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- W2054406938 doi "https://doi.org/10.1088/0952-4746/33/1/61" @default.
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