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• W2054407767 abstract "Pseudotumor cerebri syndrome (PTCS) is defined by the presence of elevated intracranial pressure (ICP) in the setting of normal brain parenchyma and cerebrospinal fluid (CSF). Headache, vision changes, and papilledema are common presenting features. Up to 10% of appropriately treated patients may experience permanent visual loss. The mechanism(s) underlying PTCS is unknown. PTCS occurs in association with a variety of conditions, including kidney disease, obesity, and adrenal insufficiency, suggesting endocrine and/or metabolic derangements may occur. Recent studies suggest that fluid and electrolyte balance in renal epithelia is regulated by a complex interaction of metabolic and hormonal factors; these cells share many of the same features as the choroid plexus cells in the central nervous system (CNS) responsible for regulation of CSF dynamics. Thus, we posit that similar factors may influence CSF dynamics in both types of fluid-sensitive tissues. Specifically, we hypothesize that, in patients with PTCS, mitochondrial metabolites (glutamate, succinate) and steroid hormones (cortisol, aldosterone) regulate CSF production and/or absorption. In this integrated mechanism review, we consider the clinical and molecular evidence for each metabolite and hormone in turn. We illustrate how related intracellular signaling cascades may converge in the choroid plexus, drawing on evidence from functionally similar tissues." @default.
• W2054407767 created "2016-06-24" @default.
• W2054407767 creator A5025121313 @default.
• W2054407767 creator A5026021396 @default.
• W2054407767 creator A5030690570 @default.
• W2054407767 creator A5039421645 @default.
• W2054407767 date "2014-11-24" @default.
• W2054407767 modified "2023-10-11" @default.
• W2054407767 title "An integrated mechanism of pediatric pseudotumor cerebri syndrome: evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics" @default.
• W2054407767 cites W1128290015 @default.
• W2054407767 cites W158788389 @default.
• W2054407767 cites W1639965093 @default.
• W2054407767 cites W1752259427 @default.
• W2054407767 cites W1764778685 @default.
• W2054407767 cites W1951887323 @default.
• W2054407767 cites W1963082309 @default.
• W2054407767 cites W1964013314 @default.
• W2054407767 cites W1964353514 @default.
• W2054407767 cites W1969932621 @default.
• W2054407767 cites W1970901539 @default.
• W2054407767 cites W1972345140 @default.
• W2054407767 cites W1976072307 @default.
• W2054407767 cites W1977137352 @default.
• W2054407767 cites W1978545347 @default.
• W2054407767 cites W1989268139 @default.
• W2054407767 cites W1993511962 @default.
• W2054407767 cites W1993565412 @default.
• W2054407767 cites W1996713062 @default.
• W2054407767 cites W1997094545 @default.
• W2054407767 cites W1997788119 @default.
• W2054407767 cites W1997887667 @default.
• W2054407767 cites W1998430905 @default.
• W2054407767 cites W1998485620 @default.
• W2054407767 cites W1999086396 @default.
• W2054407767 cites W1999289842 @default.
• W2054407767 cites W2004171169 @default.
• W2054407767 cites W2004831891 @default.
• W2054407767 cites W2010072332 @default.
• W2054407767 cites W2020217633 @default.
• W2054407767 cites W2023044809 @default.
• W2054407767 cites W2023439657 @default.
• W2054407767 cites W2029703382 @default.
• W2054407767 cites W2031866816 @default.
• W2054407767 cites W2035118791 @default.
• W2054407767 cites W2038356036 @default.
• W2054407767 cites W2042833246 @default.
• W2054407767 cites W2048093059 @default.
• W2054407767 cites W2048125598 @default.
• W2054407767 cites W2056317528 @default.
• W2054407767 cites W2059545765 @default.
• W2054407767 cites W2060701169 @default.
• W2054407767 cites W2069893007 @default.
• W2054407767 cites W2070817937 @default.
• W2054407767 cites W2075503566 @default.
• W2054407767 cites W2076680449 @default.
• W2054407767 cites W2085559528 @default.
• W2054407767 cites W2087606664 @default.
• W2054407767 cites W2087826418 @default.
• W2054407767 cites W2088694712 @default.
• W2054407767 cites W2088944774 @default.
• W2054407767 cites W2089557926 @default.
• W2054407767 cites W2092195633 @default.
• W2054407767 cites W2097169899 @default.
• W2054407767 cites W2102716024 @default.
• W2054407767 cites W2105354485 @default.
• W2054407767 cites W2107940713 @default.
• W2054407767 cites W2109272258 @default.
• W2054407767 cites W2111279651 @default.
• W2054407767 cites W2115583030 @default.
• W2054407767 cites W2115882858 @default.
• W2054407767 cites W2122367003 @default.
• W2054407767 cites W2124008907 @default.
• W2054407767 cites W2124951340 @default.
• W2054407767 cites W2128956789 @default.
• W2054407767 cites W2130024016 @default.
• W2054407767 cites W2135911722 @default.
• W2054407767 cites W2138027442 @default.
• W2054407767 cites W2140078175 @default.
• W2054407767 cites W2140714048 @default.
• W2054407767 cites W2141510314 @default.
• W2054407767 cites W2142791868 @default.
• W2054407767 cites W2144525528 @default.
• W2054407767 cites W2148536297 @default.
• W2054407767 cites W2149948417 @default.
• W2054407767 cites W2157749179 @default.
• W2054407767 cites W2162810114 @default.
• W2054407767 cites W2167066137 @default.
• W2054407767 cites W2172805006 @default.
• W2054407767 cites W2263546123 @default.
• W2054407767 cites W2318676976 @default.
• W2054407767 cites W27644166 @default.
• W2054407767 doi "https://doi.org/10.1038/pr.2014.188" @default.
• W2054407767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641240" @default.
• W2054407767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25420176" @default.
• W2054407767 hasPublicationYear "2014" @default.
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