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- W2054408934 abstract "A 4-fold induction of hepatic microsomal cytochrome P-450 following 3 days of treatment of rats with clotrimazole (75 mg/kg), a potent monooxygenase inhibitor, greatly exceeded that evident from similar phenobarbital and dexamethasone treatment. The clotrimazole-induced microsomes exhibited a pattern of monooxygenase activities similar to that seen in microsomes from both phenobarbital- and dexamethasone-treated animals. Precautions were necessary to determine both monooxygenase activities and the full amount of cytochrome P-450 present in microsomes because of interference by residual clotrimazole in the microsomes." @default.
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- W2054408934 date "1987-09-01" @default.
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- W2054408934 title "High magnitude hepatic cytochrome P-450 induction by an N-substituted imidazole antimycotic, clotrimazole" @default.
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- W2054408934 doi "https://doi.org/10.1016/0006-2952(87)90265-6" @default.
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