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- W2054408979 abstract "J. Neurochem . (2009) 109 , 792–806. Abstract The neuropeptide vasoactive intestinal peptide (VIP) is anti‐inflammatory and protective in the immune and nervous systems, respectively. This study demonstrated in corneal endothelial (CE) cells injured by severe oxidative stress (1.4 mM H 2 O 2 ) in bovine corneal organ cultures that VIP pre‐treatment (0, 10 −10 , 10 −8 , and 10 −6 M; 15 min), in a VIP concentration‐dependent manner, switched the inflammation‐causing necrosis to inflammation‐neutral apoptosis (showing annexin V‐binding, chromatin condensation, and DNA fragmentation) and upheld ATP levels in a VIP antagonist (SN)VIPhyb‐sensitive manner, while up‐regulated mRNA levels of the anti‐apoptotic Bcl‐2 and the differentiation marker N‐cadherin in a kinase A inhibitor‐sensitive manner. As a result, VIP, in a concentration‐dependent and VIP antagonist‐sensitive manners, promoted long‐term CE cell survival. ATP levels, a determining factor in the choice of apoptosis versus necrosis, measured after VIP pre‐treatment and 0.5 min post‐H 2 O 2 were 39.6 ± 3.3, 50.8 ± 6.2, 60.1 ± 4.8, and 53.6 ± 5.3 pmoles/μg protein (mean ± SEM), respectively ( p < 0.05, anova ). VIP treatment alone concentration‐dependently increased levels of N‐cadherin ( Koh et al. 2008 ), the phosphorylated cAMP‐responsive‐element binding protein and Bcl‐2, while10 −8 M VIP, in a VIP antagonist (SN)VIPhyb‐sensitive manner, increased ATP level by 38% ( p < 0.02) and decreased glycogen level by 32% ( p < 0.02). VPAC1 (not VPAC2) receptor was expressed in CE cells. Thus, CE cell VIP/VPAC1 signaling is both anti‐inflammatory and protective in the corneal endothelium." @default.
- W2054408979 created "2016-06-24" @default.
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- W2054408979 date "2009-04-07" @default.
- W2054408979 modified "2023-10-16" @default.
- W2054408979 title "VIP down-regulates the inflammatory potential and promotes survival of dying (neural crest-derived) corneal endothelial cells<i>ex vivo</i>: necrosis to apoptosis switch and up-regulation of Bcl-2 and N-cadherin" @default.
- W2054408979 cites W1510067290 @default.
- W2054408979 cites W1549474609 @default.
- W2054408979 cites W1582706141 @default.
- W2054408979 cites W1588651725 @default.
- W2054408979 cites W1614322283 @default.
- W2054408979 cites W1800864886 @default.
- W2054408979 cites W1874291746 @default.
- W2054408979 cites W1915121024 @default.
- W2054408979 cites W1966210575 @default.
- W2054408979 cites W1972182945 @default.
- W2054408979 cites W1974176915 @default.
- W2054408979 cites W1975468879 @default.
- W2054408979 cites W1978900962 @default.
- W2054408979 cites W1979542318 @default.
- W2054408979 cites W1983069749 @default.
- W2054408979 cites W1987680648 @default.
- W2054408979 cites W1989154219 @default.
- W2054408979 cites W1990657415 @default.
- W2054408979 cites W1990970518 @default.
- W2054408979 cites W1992231858 @default.
- W2054408979 cites W1995127057 @default.
- W2054408979 cites W1998555534 @default.
- W2054408979 cites W1999952910 @default.
- W2054408979 cites W2005883891 @default.
- W2054408979 cites W2007076173 @default.
- W2054408979 cites W2014761527 @default.
- W2054408979 cites W2014932742 @default.
- W2054408979 cites W2016772796 @default.
- W2054408979 cites W2018088198 @default.
- W2054408979 cites W2021049313 @default.
- W2054408979 cites W2025695096 @default.
- W2054408979 cites W2037781976 @default.
- W2054408979 cites W2038934400 @default.
- W2054408979 cites W2039436584 @default.
- W2054408979 cites W2041793845 @default.
- W2054408979 cites W2048547348 @default.
- W2054408979 cites W2049439285 @default.
- W2054408979 cites W2051148579 @default.
- W2054408979 cites W2055132644 @default.
- W2054408979 cites W2056016404 @default.
- W2054408979 cites W2056707198 @default.
- W2054408979 cites W2057064377 @default.
- W2054408979 cites W2057885957 @default.
- W2054408979 cites W2060139749 @default.
- W2054408979 cites W2062930328 @default.
- W2054408979 cites W2063147924 @default.
- W2054408979 cites W2065742667 @default.
- W2054408979 cites W2071244928 @default.
- W2054408979 cites W2071983092 @default.
- W2054408979 cites W2074213282 @default.
- W2054408979 cites W2078063257 @default.
- W2054408979 cites W2078532650 @default.
- W2054408979 cites W2082905439 @default.
- W2054408979 cites W2083299002 @default.
- W2054408979 cites W2087695355 @default.
- W2054408979 cites W2087917186 @default.
- W2054408979 cites W2094943813 @default.
- W2054408979 cites W2096293112 @default.
- W2054408979 cites W2097585375 @default.
- W2054408979 cites W2108113233 @default.
- W2054408979 cites W2110412870 @default.
- W2054408979 cites W2111255046 @default.
- W2054408979 cites W2123759954 @default.
- W2054408979 cites W2126497605 @default.
- W2054408979 cites W2130956571 @default.
- W2054408979 cites W2134160865 @default.
- W2054408979 cites W2135325091 @default.
- W2054408979 cites W2138071274 @default.
- W2054408979 cites W2139410513 @default.
- W2054408979 cites W2150642049 @default.
- W2054408979 cites W2152099551 @default.
- W2054408979 cites W2152205887 @default.
- W2054408979 cites W2160389693 @default.
- W2054408979 cites W2163785160 @default.
- W2054408979 cites W2167378179 @default.
- W2054408979 cites W2171744721 @default.
- W2054408979 cites W2326120845 @default.
- W2054408979 doi "https://doi.org/10.1111/j.1471-4159.2009.06012.x" @default.
- W2054408979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2702518" @default.
- W2054408979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19250342" @default.
- W2054408979 hasPublicationYear "2009" @default.
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