FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054409347> ?p ?o ?g. }

• W2054409347 endingPage "8808" @default.
• W2054409347 startingPage "8798" @default.
• W2054409347 abstract "Engineering bone tissue is particularly challenging because of the distinctive structural features of bone within a complex biochemical environment. In the present study, we fabricated poly(L-lactic acid) (PLLA) electrospun nanofibers with random and aligned morphology immobilized with bone morphogenic protein-2 (BMP-2) and investigated how these signals modulate (1) in vitro osteogenic differentiation of human mesenchymal stem cells (hMSCs) and (2) in vivo bone growth rate, mechanical properties, and collagen assembly of newly formed bone. The orientation of adherent cells followed the underlying nanofiber morphology; however, nanofiber alignment did not show any difference in alkaline phosphate activity or in calcium mineralization of hMSCs after 14 days of in vitro culture in osteogenic differentiation media. In vivo bone regeneration was significantly higher in the nanofiber implanted groups (approximately 65-79%) as compared to the defect-only group (11.8 ± 0.2%), while no significant difference in bone regeneration was observed between random and aligned groups. However, nanoindentation studies of regenerated bone revealed Young's modulus and contact hardness with anisotropic feature for aligned group as compared to random group. More importantly, structural analysis of collagen at de novo bone showed the ability of nanofiber morphology to guide collagen deposition. SEM and TEM images revealed regular, highly ordered collagen assemblies on aligned nanofibers as compared to random fibers, which showed irregular, randomly organized collagen deposition. Taken together, we conclude that nanofibers in the presence of osteoinductive signals are a potent tool for bone regeneration, and nanofiber alignment can be used for engineering bone tissues with structurally assembled collagen fibers with defined direction." @default.
• W2054409347 created "2016-06-24" @default.
• W2054409347 creator A5044124597 @default.
• W2054409347 creator A5046146264 @default.
• W2054409347 creator A5057631043 @default.
• W2054409347 creator A5062317501 @default.
• W2054409347 creator A5072397615 @default.
• W2054409347 creator A5074929175 @default.
• W2054409347 creator A5084434329 @default.
• W2054409347 date "2015-04-14" @default.
• W2054409347 modified "2023-10-18" @default.
• W2054409347 title "Effects of Immobilized BMP-2 and Nanofiber Morphology on In Vitro Osteogenic Differentiation of hMSCs and In Vivo Collagen Assembly of Regenerated Bone" @default.
• W2054409347 cites W118283319 @default.
• W2054409347 cites W1553015155 @default.
• W2054409347 cites W1581139648 @default.
• W2054409347 cites W1920761902 @default.
• W2054409347 cites W1968499052 @default.
• W2054409347 cites W1973045888 @default.
• W2054409347 cites W1981338745 @default.
• W2054409347 cites W1983239185 @default.
• W2054409347 cites W1983865998 @default.
• W2054409347 cites W1987787819 @default.
• W2054409347 cites W1994108879 @default.
• W2054409347 cites W1998497131 @default.
• W2054409347 cites W2004376369 @default.
• W2054409347 cites W2011995182 @default.
• W2054409347 cites W2017621114 @default.
• W2054409347 cites W2021611413 @default.
• W2054409347 cites W2022554508 @default.
• W2054409347 cites W2026314224 @default.
• W2054409347 cites W2030251910 @default.
• W2054409347 cites W2033954341 @default.
• W2054409347 cites W2042849291 @default.
• W2054409347 cites W2044203477 @default.
• W2054409347 cites W2045095867 @default.
• W2054409347 cites W2046796767 @default.
• W2054409347 cites W2051643498 @default.
• W2054409347 cites W2053441352 @default.
• W2054409347 cites W2055245979 @default.
• W2054409347 cites W2057937678 @default.
• W2054409347 cites W2061263014 @default.
• W2054409347 cites W2064404217 @default.
• W2054409347 cites W2068920949 @default.
• W2054409347 cites W2080790182 @default.
• W2054409347 cites W2082764627 @default.
• W2054409347 cites W2085269784 @default.
• W2054409347 cites W2085365047 @default.
• W2054409347 cites W2092858957 @default.
• W2054409347 cites W2093483666 @default.
• W2054409347 cites W2099821568 @default.
• W2054409347 cites W2130568296 @default.
• W2054409347 cites W2131943899 @default.
• W2054409347 cites W2132551393 @default.
• W2054409347 cites W2139636340 @default.
• W2054409347 cites W2148533274 @default.
• W2054409347 cites W2158938188 @default.
• W2054409347 cites W2159185781 @default.
• W2054409347 cites W2160803146 @default.
• W2054409347 cites W2162267367 @default.
• W2054409347 cites W2314653534 @default.
• W2054409347 cites W2319860567 @default.
• W2054409347 doi "https://doi.org/10.1021/acsami.5b01340" @default.
• W2054409347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25823598" @default.
• W2054409347 hasPublicationYear "2015" @default.
• W2054409347 type Work @default.
• W2054409347 sameAs 2054409347 @default.
• W2054409347 citedByCount "56" @default.
• W2054409347 countsByYear W20544093472015 @default.
• W2054409347 countsByYear W20544093472016 @default.
• W2054409347 countsByYear W20544093472017 @default.
• W2054409347 countsByYear W20544093472018 @default.
• W2054409347 countsByYear W20544093472019 @default.
• W2054409347 countsByYear W20544093472020 @default.
• W2054409347 countsByYear W20544093472021 @default.
• W2054409347 countsByYear W20544093472022 @default.
• W2054409347 countsByYear W20544093472023 @default.
• W2054409347 crossrefType "journal-article" @default.
• W2054409347 hasAuthorship W2054409347A5044124597 @default.
• W2054409347 hasAuthorship W2054409347A5046146264 @default.
• W2054409347 hasAuthorship W2054409347A5057631043 @default.
• W2054409347 hasAuthorship W2054409347A5062317501 @default.
• W2054409347 hasAuthorship W2054409347A5072397615 @default.
• W2054409347 hasAuthorship W2054409347A5074929175 @default.
• W2054409347 hasAuthorship W2054409347A5084434329 @default.
• W2054409347 hasConcept C12554922 @default.
• W2054409347 hasConcept C136229726 @default.
• W2054409347 hasConcept C150903083 @default.
• W2054409347 hasConcept C160160445 @default.
• W2054409347 hasConcept C171250308 @default.
• W2054409347 hasConcept C181199279 @default.
• W2054409347 hasConcept C185592680 @default.
• W2054409347 hasConcept C192562407 @default.
• W2054409347 hasConcept C198826908 @default.
• W2054409347 hasConcept C207001950 @default.
• W2054409347 hasConcept C49892992 @default.
• W2054409347 hasConcept C55493867 @default.
• W2054409347 hasConcept C71924100 @default.
• W2054409347 hasConcept C86803240 @default.

• next