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• W2054415013 abstract "Serotonin-1F receptor (5-HT1F) agonists may relieve acute migraine without vasoconstriction. We conducted a review of preclinical and clinical data that assessed the potential link between migraine and 5-HT1F activation. (i) A high correlation exists between the potency of various 5-HT1 receptor agonists in the guinea pig dural plasma protein extravasation assay and their 5-HT1F receptor binding affinity. (ii) 5-HT1F receptors are on the trigeminal system, and may participate in blocking migraine pain transmission through the trigeminal ganglion and nucleus caudalis. (iii) 5-HT1F receptors are located on glutamate-containing neurones and their activation might inhibit glutamate release; glutamate excess may play a role in migraine. (iv) Selective 5-HT1F receptor agonists (LY334370; LY344864) are effective in preclinical migraine models and are non-vasoconstrictive. (v) LY334370 is effective in acute migraine, and does not cause any symptoms/signs of coronary vasoconstriction. Preclinical experiments and clinical observations argue for a role of selective 5-HT1F agonists in migraine." @default.
• W2054415013 created "2016-06-24" @default.
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• W2054415013 date "2003-10-01" @default.
• W2054415013 modified "2023-10-14" @default.
• W2054415013 title "5-HT_1F Receptor Agonists in Acute Migraine Treatment: A Hypothesis" @default.
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• W2054415013 doi "https://doi.org/10.1046/j.1468-2982.2003.00525.x" @default.
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