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- W2054418621 abstract "Abstract The acute toxicity of obidoxime and its effects on neuromuscular transmission were studied in rats previously treated with atropine and fluostigmine. A single injection of atropine and fluostigmine (2 mg/kg sc) was given and then obidoxime was administered after 3, 24, 48, or 72 hr. It was demonstrated that the LD50 of obidoxime in animals previously pretreated was significantly decreased. The concentration of obidoxime required to give an equivalent block of twitch response in the rat phrenic nerve-diaphragm preparation was markedly lower in rats pretreated with fluostigmine and atropine than in control animals. The greatest increase in sensitivity to obidoxime was seen 48 hr following fluostigmine administration." @default.
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- W2054418621 date "1978-11-01" @default.
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- W2054418621 title "Increase in sensitivity to obidoxime induced by fluostigmine in the rat" @default.
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- W2054418621 doi "https://doi.org/10.1016/0041-008x(78)90088-1" @default.
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