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• W2054420772 abstract "The aim of this study was to evaluate the in-vivo behaviour of matrix pellets formulated with nanocrystalline ketoprofen after oral administration to dogs. No significant differences in AUC-values were seen between pellet formulations containing nanocrystalline or microcrystalline ketoprofen and a commercial ketoprofen formulation (reference: Rofenid 200 Long Acting). C(max) of the formulations containing nano- or microcrystalline ketoprofen was significantly higher compared to reference, whereas t(max) was significantly lower. The in-vivo burst release observed for the spray dried nanocrystalline ketoprofen matrix pellets was reduced following compression of the pellets in combination with placebo wax/starch pellets. These matrix tablets sustained the ketoprofen plasma concentrations during 5.6 and 5.4 h for formulations containing nano- and microcrystalline ketoprofen, respectively." @default.
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• W2054420772 date "2002-06-01" @default.
• W2054420772 modified "2023-09-24" @default.
• W2054420772 title "In vivo evaluation of matrix pellets containing nanocrystalline ketoprofen" @default.
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• W2054420772 doi "https://doi.org/10.1016/s0378-5173(02)00114-x" @default.
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