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• W2054428208 abstract "Two families of glucose transporter – the Na+-dependent glucose cotransporter-1 (SGLT family) and the facilitated diffusion glucose transporter family (GLUT family) – play a crucial role in the translocation of glucose across the epithelial cell membrane. How genetic mutations cause life-threatening diseases like GLUT1-deficiency syndrome (GLUT1-DS) is not well understood. In this review, we have combined previous functional data with our in silico analyses of the bacterial homologue of GLUT members, XylE (an outward-facing, partly occluded conformation) and previously proposed GLUT1 homology model (an inward-facing conformation). A variety of native and mutant side chain interactions were modeled to highlight the potential roles of mutations in destabilizing protein–protein interaction hence triggering structural and functional defects. This study sets the stage for future studies of the structural properties that mediate GLUT1 dysfunction and further suggests that both SGLT and GLUT families share conserved domains that stabilize the transporter structure/function via a similar mechanism." @default.
• W2054428208 created "2016-06-24" @default.
• W2054428208 creator A5060543020 @default.
• W2054428208 creator A5076454686 @default.
• W2054428208 date "2015-05-01" @default.
• W2054428208 modified "2023-09-25" @default.
• W2054428208 title "Pathogenic mutations causing glucose transport defects in GLUT1 transporter: The role of intermolecular forces in protein structure-function" @default.
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• W2054428208 doi "https://doi.org/10.1016/j.bpc.2015.03.005" @default.
• W2054428208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25863194" @default.
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