FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054433076> ?p ?o ?g. }

• W2054433076 endingPage "92" @default.
• W2054433076 startingPage "87" @default.
• W2054433076 abstract "Enzyme replacement therapy (ERT) has proven to be an effective therapy for some lysosomal storage disorder (LSD) patients. A potential complication during ERT is the generation of an immune response against the replacement protein. We have investigated the antigenicity of two distantly related glycosidases, alpha-glucosidase (Pompe disease or glycogen storage disease type II, GSD II), and alpha-L-iduronidase (Hurler syndrome, mucopolysaccharidosis type I, MPS I). The linear sequence epitope reactivity of affinity purified polyclonal antibodies to recombinant human alpha-glucosidase and alpha-L-iduronidase was defined, to both glycosidases. The polyclonal antibodies exhibited some cross-reactive epitopes on the two proteins. Moreover, a monoclonal antibody to the active site of alpha-glucosidase showed cross-reactivity with a catalytic structural element of alpha-L-iduronidase. In a previous study, in MPS I patients who developed an immune response to ERT, this same site on alpha-L-iduronidase was highly antigenic and the last to tolerise following repeated enzyme infusions. We conclude that glycosidases can exhibit cross-reactive epitopes, and infer that this may relate to common structural elements associated with their active sites." @default.
• W2054433076 created "2016-06-24" @default.
• W2054433076 creator A5010188514 @default.
• W2054433076 creator A5022486673 @default.
• W2054433076 creator A5035311379 @default.
• W2054433076 creator A5038474565 @default.
• W2054433076 creator A5042169811 @default.
• W2054433076 creator A5049954577 @default.
• W2054433076 creator A5083064307 @default.
• W2054433076 date "2005-12-06" @default.
• W2054433076 modified "2023-09-30" @default.
• W2054433076 title "Common antigenicity for two glycosidases" @default.
• W2054433076 cites W1562852007 @default.
• W2054433076 cites W1624669825 @default.
• W2054433076 cites W1786920819 @default.
• W2054433076 cites W1830745998 @default.
• W2054433076 cites W1971003485 @default.
• W2054433076 cites W1978230195 @default.
• W2054433076 cites W1978337429 @default.
• W2054433076 cites W1983318494 @default.
• W2054433076 cites W2001805850 @default.
• W2054433076 cites W2015761210 @default.
• W2054433076 cites W2019308804 @default.
• W2054433076 cites W2037891557 @default.
• W2054433076 cites W2039731257 @default.
• W2054433076 cites W2062886670 @default.
• W2054433076 cites W2072849873 @default.
• W2054433076 cites W2105778681 @default.
• W2054433076 cites W2106121486 @default.
• W2054433076 cites W2109581185 @default.
• W2054433076 cites W2123276411 @default.
• W2054433076 cites W2136255603 @default.
• W2054433076 cites W2143869612 @default.
• W2054433076 cites W2149464124 @default.
• W2054433076 cites W2169156514 @default.
• W2054433076 cites W2950469006 @default.
• W2054433076 doi "https://doi.org/10.1016/j.febslet.2005.11.053" @default.
• W2054433076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16359666" @default.
• W2054433076 hasPublicationYear "2005" @default.
• W2054433076 type Work @default.
• W2054433076 sameAs 2054433076 @default.
• W2054433076 citedByCount "1" @default.
• W2054433076 crossrefType "journal-article" @default.
• W2054433076 hasAuthorship W2054433076A5010188514 @default.
• W2054433076 hasAuthorship W2054433076A5022486673 @default.
• W2054433076 hasAuthorship W2054433076A5035311379 @default.
• W2054433076 hasAuthorship W2054433076A5038474565 @default.
• W2054433076 hasAuthorship W2054433076A5042169811 @default.
• W2054433076 hasAuthorship W2054433076A5049954577 @default.
• W2054433076 hasAuthorship W2054433076A5083064307 @default.
• W2054433076 hasBestOaLocation W20544330761 @default.
• W2054433076 hasConcept C126322002 @default.
• W2054433076 hasConcept C147483822 @default.
• W2054433076 hasConcept C153911025 @default.
• W2054433076 hasConcept C159654299 @default.
• W2054433076 hasConcept C185592680 @default.
• W2054433076 hasConcept C195616568 @default.
• W2054433076 hasConcept C203014093 @default.
• W2054433076 hasConcept C2779026604 @default.
• W2054433076 hasConcept C2779134260 @default.
• W2054433076 hasConcept C2779969927 @default.
• W2054433076 hasConcept C2781241564 @default.
• W2054433076 hasConcept C542903549 @default.
• W2054433076 hasConcept C55493867 @default.
• W2054433076 hasConcept C71924100 @default.
• W2054433076 hasConcept C86803240 @default.
• W2054433076 hasConcept C956191 @default.
• W2054433076 hasConceptScore W2054433076C126322002 @default.
• W2054433076 hasConceptScore W2054433076C147483822 @default.
• W2054433076 hasConceptScore W2054433076C153911025 @default.
• W2054433076 hasConceptScore W2054433076C159654299 @default.
• W2054433076 hasConceptScore W2054433076C185592680 @default.
• W2054433076 hasConceptScore W2054433076C195616568 @default.
• W2054433076 hasConceptScore W2054433076C203014093 @default.
• W2054433076 hasConceptScore W2054433076C2779026604 @default.
• W2054433076 hasConceptScore W2054433076C2779134260 @default.
• W2054433076 hasConceptScore W2054433076C2779969927 @default.
• W2054433076 hasConceptScore W2054433076C2781241564 @default.
• W2054433076 hasConceptScore W2054433076C542903549 @default.
• W2054433076 hasConceptScore W2054433076C55493867 @default.
• W2054433076 hasConceptScore W2054433076C71924100 @default.
• W2054433076 hasConceptScore W2054433076C86803240 @default.
• W2054433076 hasConceptScore W2054433076C956191 @default.
• W2054433076 hasIssue "1" @default.
• W2054433076 hasLocation W20544330761 @default.
• W2054433076 hasLocation W20544330762 @default.
• W2054433076 hasLocation W20544330763 @default.
• W2054433076 hasLocation W20544330764 @default.
• W2054433076 hasLocation W20544330765 @default.
• W2054433076 hasOpenAccess W2054433076 @default.
• W2054433076 hasPrimaryLocation W20544330761 @default.
• W2054433076 hasRelatedWork W1604248381 @default.
• W2054433076 hasRelatedWork W2018051677 @default.
• W2054433076 hasRelatedWork W2037509311 @default.
• W2054433076 hasRelatedWork W2062700146 @default.
• W2054433076 hasRelatedWork W2071487707 @default.
• W2054433076 hasRelatedWork W2082936079 @default.
• W2054433076 hasRelatedWork W2386118910 @default.

• next