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• W2054435056 startingPage "29" @default.
• W2054435056 abstract "The cloning of the melanocortin-1 receptor (MC1R) gene from human melanocytes and the demonstration that these cells respond to the melanocortins alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) with increased proliferation and melanogenesis have renewed the interest in investigation the physiological role of these hormones in regulating human pigmentation. Alpha-melanocyte stimulating hormone and ACTH are both synthesized in the human epidermis, and their synthesis is upregulated by exposure to ultraviolet radiation (UVR). Activation of the MC1R by ligand binding results in stimulation of cAMP formation, which is a principal mechanism for inducing melanogenesis. The increase in cAMP is required for the pigmentary response of human melanocytes to UVR, and for allowing them to overcome the UVR-induced G1 arrest. Treatment of human melanocytes with alpha-MSH increases eumelanin synthesis, an effect that is expected to enhance photoprotection of the skin. Population studies have revealed more than 20 allelic variants of the MC1R gene. Some of these variants are overexpressed in individuals with skin type I or II, red hair, and poor tanning ability. Future studies will aim at further exploration of the role of these variants in MC1R function, and in determining constitutive human pigmentation, the response to sun exposure, and possibly the susceptibility to skin cancer." @default.
• W2054435056 created "2016-06-24" @default.
• W2054435056 creator A5000061916 @default.
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• W2054435056 date "1999-09-01" @default.
• W2054435056 modified "2023-10-16" @default.
• W2054435056 title "Participation of the Melanocortin-1 Receptor in the UV Control of Pigmentation" @default.
• W2054435056 cites W1573305724 @default.
• W2054435056 cites W1577847062 @default.
• W2054435056 cites W1590127176 @default.
• W2054435056 cites W1748312647 @default.
• W2054435056 cites W1966400763 @default.
• W2054435056 cites W1967714178 @default.
• W2054435056 cites W1968806208 @default.
• W2054435056 cites W1971189597 @default.
• W2054435056 cites W1979451321 @default.
• W2054435056 cites W1980410097 @default.
• W2054435056 cites W1981362058 @default.
• W2054435056 cites W1983219118 @default.
• W2054435056 cites W1984552079 @default.
• W2054435056 cites W1984610550 @default.
• W2054435056 cites W1988996984 @default.
• W2054435056 cites W1990156840 @default.
• W2054435056 cites W1991635026 @default.
• W2054435056 cites W1993708071 @default.
• W2054435056 cites W1996926729 @default.
• W2054435056 cites W1997783712 @default.
• W2054435056 cites W1999829508 @default.
• W2054435056 cites W2000919184 @default.
• W2054435056 cites W2003507585 @default.
• W2054435056 cites W2003650919 @default.
• W2054435056 cites W2005664558 @default.
• W2054435056 cites W2009626008 @default.
• W2054435056 cites W2012550606 @default.
• W2054435056 cites W2017717368 @default.
• W2054435056 cites W2018094960 @default.
• W2054435056 cites W2018115687 @default.
• W2054435056 cites W2018556537 @default.
• W2054435056 cites W2018908952 @default.
• W2054435056 cites W2023020722 @default.
• W2054435056 cites W2023610505 @default.
• W2054435056 cites W2031971375 @default.
• W2054435056 cites W2033076037 @default.
• W2054435056 cites W2041659572 @default.
• W2054435056 cites W2041797639 @default.
• W2054435056 cites W2042153435 @default.
• W2054435056 cites W2045895711 @default.
• W2054435056 cites W2048953807 @default.
• W2054435056 cites W2051395442 @default.
• W2054435056 cites W2054757478 @default.
• W2054435056 cites W2055562285 @default.
• W2054435056 cites W2058978176 @default.
• W2054435056 cites W2059168179 @default.
• W2054435056 cites W2062499160 @default.
• W2054435056 cites W2064350910 @default.
• W2054435056 cites W2066757189 @default.
• W2054435056 cites W2067379696 @default.
• W2054435056 cites W2068483472 @default.
• W2054435056 cites W2068583473 @default.
• W2054435056 cites W2070913478 @default.
• W2054435056 cites W2071596792 @default.
• W2054435056 cites W2072350011 @default.
• W2054435056 cites W2072543946 @default.
• W2054435056 cites W2073896057 @default.
• W2054435056 cites W2080028916 @default.
• W2054435056 cites W2080989437 @default.
• W2054435056 cites W2082557627 @default.
• W2054435056 cites W2084040385 @default.
• W2054435056 cites W2085459574 @default.
• W2054435056 cites W2090650873 @default.
• W2054435056 cites W2090985333 @default.
• W2054435056 cites W2093226165 @default.
• W2054435056 cites W2095194956 @default.
• W2054435056 cites W2095208294 @default.
• W2054435056 cites W2095641765 @default.
• W2054435056 cites W2097131232 @default.
• W2054435056 cites W2101722758 @default.
• W2054435056 cites W2102654270 @default.
• W2054435056 cites W2103729173 @default.
• W2054435056 cites W2107248656 @default.
• W2054435056 cites W2107435981 @default.
• W2054435056 cites W2108913458 @default.
• W2054435056 cites W2111436354 @default.
• W2054435056 cites W2117888324 @default.
• W2054435056 cites W2120856340 @default.
• W2054435056 cites W2126436114 @default.
• W2054435056 cites W2128443448 @default.
• W2054435056 cites W2138668121 @default.
• W2054435056 cites W2138835510 @default.
• W2054435056 cites W2141449954 @default.
• W2054435056 cites W2149538815 @default.

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