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• W2054452904 abstract "Objective: Although conventional radiography is used to assess osteoarthritis in a clinical setting, it has limitations, including an inability to stage early cartilage degeneration. There is a growing interest in using quantitative magnetic resonance imaging to identify degenerative changes in articular cartilage, including the large multicentered study, the Osteoarthritis Initiative (OAI). There is a demand for suitable image registration and segmentation software to complete this analysis. The objective of this study was to develop and validate the open source software, ImageK, that registers 3 T MRI T2 mapping and double echo steady state (DESS) knee MRI sequences acquired in the OAI protocol. Methods: A C++ library, the insight toolkit, was used to develop open source software to register DESS and T2 mapping image MRI sequences using Mattes’s Multimodality Mutual information metric. Results: Registration was assessed using three separate methods. A checkerboard layout demonstrated acceptable visual alignment. Fiducial markers placed in cadaveric knees measured a registration error of 0.85 voxels. Measuring the local variation in Mattes’s Mutual Information metric in the local area of the registered solution showed precision within 1 pixel. In this group, the registered solution required a transform of 56 voxels in translation and 1 degree of rotation. Conclusion: The software we have developed, ImageK, provides free, open source image analysis software that registers DESS and T2 mapping sequences of knee articular cartilage within 1 voxel accuracy. This image registration software facilitates quantitative MRI analyses of knee articular cartilage." @default.
• W2054452904 created "2016-06-24" @default.
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• W2054452904 date "2012-09-26" @default.
• W2054452904 modified "2023-09-29" @default.
• W2054452904 title "Registration of Magnetic Resonance Image Series for Knee Articular Cartilage Analysis" @default.
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• W2054452904 doi "https://doi.org/10.1177/1947603512451745" @default.
• W2054452904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3753048" @default.
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• W2054452904 hasPublicationYear "2012" @default.
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