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- W2054492080 endingPage "1372" @default.
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- W2054492080 abstract "The incidence of lymphoma in patients with HIV infection greatly exceeds that of the general population. The increased risk for lymphoma appears related to multiple factors, including the transforming properties of the retrovirus itself, the immunosuppression and cytokine dysregulation that results from the disease, and, most importantly, opportunistic infections with other lymphotrophic herpes viruses such as Epstein-Barr virus and human herpesvirus 8. Histologically lymphomas fall into three groups: (1) those also occurring in immunocompetent patients; (2) those occurring more specifically in HIV-positive patients; and (3) those also occurring in patients with other forms of immunosuppression. Aggressive lymphomas account for the vast majority cases. They frequently present with advanced stage, bulky disease with high tumour burden and, typically, involve extranodal sites. Clinical outcome appears to be worse than in similar aggressive lymphomas in the general population. However, following the introduction of highly active antiretroviral therapy, the risk for developing lymphoma in the context of HIV infection has decreased and the clinical outcome has improved." @default.
- W2054492080 created "2016-06-24" @default.
- W2054492080 creator A5024505450 @default.
- W2054492080 creator A5026248947 @default.
- W2054492080 creator A5049329206 @default.
- W2054492080 date "2006-12-20" @default.
- W2054492080 modified "2023-09-26" @default.
- W2054492080 title "HIV infection and lymphoma" @default.
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- W2054492080 doi "https://doi.org/10.1136/jcp.2007.051953" @default.
- W2054492080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2095580" @default.
- W2054492080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18042692" @default.
- W2054492080 hasPublicationYear "2006" @default.
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