FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054504845> ?p ?o ?g. }

• W2054504845 endingPage "6495" @default.
• W2054504845 startingPage "6483" @default.
• W2054504845 abstract "ABSTRACT The epidermal growth factor receptor (EGFR) family regulates essential biological processes. Various epithelial tumors are linked to EGFR overexpression or expression of variant forms, such as the EGFR1 variant, EGFRvIII. Perturbations in expression of the transcription initiation factor, TATA-binding protein (TBP), alter cellular growth properties. Here we demonstrate that EGFR1 and EGFRvIII, but not HER2, induce TBP expression at a transcriptional level through distinct mechanisms. EGFR1 enhances the phosphorylation and function of Elk-1, recruiting it to the TBP promoter. In contrast, EGFRvIII robustly induces c-jun expression, stimulating recruitment of c-fos/c-jun to an overlapping AP-1 site. Enhancing c-jun expression alone induces TBP promoter activity through the AP-1 site. To determine the underlying mechanism for differences in Elk-1 function and c-jun expression by these receptors, we inhibited the internalization of EGFR1. Persistent EGFR1 cell surface occupancy mimics EGFRvIII-mediated effects on Elk-1 and c-jun and switches the requirement of Elk-1 to AP-1 for TBP promoter induction. Together, these studies define a new molecular mechanism for the regulation of TBP expression. In addition, we identify distinct molecular targets of EGFR1 and EGFRvIII and demonstrate the importance of receptor internalization in distinguishing their specific functions." @default.
• W2054504845 created "2016-06-24" @default.
• W2054504845 creator A5041411861 @default.
• W2054504845 creator A5043073689 @default.
• W2054504845 creator A5067930144 @default.
• W2054504845 date "2008-10-15" @default.
• W2054504845 modified "2023-09-25" @default.
• W2054504845 title "Epidermal Growth Factor Receptor 1 (EGFR1) and Its Variant EGFRvIII Regulate TATA-Binding Protein Expression through Distinct Pathways" @default.
• W2054504845 cites W1489145507 @default.
• W2054504845 cites W1520023565 @default.
• W2054504845 cites W1586063227 @default.
• W2054504845 cites W1823105562 @default.
• W2054504845 cites W1945507556 @default.
• W2054504845 cites W1971911912 @default.
• W2054504845 cites W1975082399 @default.
• W2054504845 cites W1977565167 @default.
• W2054504845 cites W1978177843 @default.
• W2054504845 cites W1982024613 @default.
• W2054504845 cites W1982720770 @default.
• W2054504845 cites W1984536659 @default.
• W2054504845 cites W1991545343 @default.
• W2054504845 cites W1997075903 @default.
• W2054504845 cites W1998130451 @default.
• W2054504845 cites W2000082154 @default.
• W2054504845 cites W2009424879 @default.
• W2054504845 cites W2013878898 @default.
• W2054504845 cites W2013900075 @default.
• W2054504845 cites W2014635214 @default.
• W2054504845 cites W2016929854 @default.
• W2054504845 cites W2023563217 @default.
• W2054504845 cites W2041880278 @default.
• W2054504845 cites W2045893328 @default.
• W2054504845 cites W2046369212 @default.
• W2054504845 cites W2060037522 @default.
• W2054504845 cites W2061096783 @default.
• W2054504845 cites W2061671663 @default.
• W2054504845 cites W2061701210 @default.
• W2054504845 cites W2067005574 @default.
• W2054504845 cites W2068638497 @default.
• W2054504845 cites W2068789057 @default.
• W2054504845 cites W2072319964 @default.
• W2054504845 cites W2073209811 @default.
• W2054504845 cites W2097155763 @default.
• W2054504845 cites W2100725203 @default.
• W2054504845 cites W2105086994 @default.
• W2054504845 cites W2106220021 @default.
• W2054504845 cites W2127041394 @default.
• W2054504845 cites W2132754910 @default.
• W2054504845 cites W2141902279 @default.
• W2054504845 cites W2143812122 @default.
• W2054504845 cites W2145460819 @default.
• W2054504845 cites W2148253349 @default.
• W2054504845 cites W2150762830 @default.
• W2054504845 cites W2150942934 @default.
• W2054504845 cites W2161972131 @default.
• W2054504845 cites W2162472689 @default.
• W2054504845 cites W2164154631 @default.
• W2054504845 cites W2179537743 @default.
• W2054504845 cites W4211075026 @default.
• W2054504845 cites W4234429443 @default.
• W2054504845 cites W82675992 @default.
• W2054504845 cites W912507531 @default.
• W2054504845 doi "https://doi.org/10.1128/mcb.00288-08" @default.
• W2054504845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2577416" @default.
• W2054504845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18710943" @default.
• W2054504845 hasPublicationYear "2008" @default.
• W2054504845 type Work @default.
• W2054504845 sameAs 2054504845 @default.
• W2054504845 citedByCount "21" @default.
• W2054504845 countsByYear W20545048452012 @default.
• W2054504845 countsByYear W20545048452013 @default.
• W2054504845 countsByYear W20545048452016 @default.
• W2054504845 countsByYear W20545048452017 @default.
• W2054504845 countsByYear W20545048452018 @default.
• W2054504845 countsByYear W20545048452019 @default.
• W2054504845 countsByYear W20545048452020 @default.
• W2054504845 countsByYear W20545048452021 @default.
• W2054504845 countsByYear W20545048452022 @default.
• W2054504845 crossrefType "journal-article" @default.
• W2054504845 hasAuthorship W2054504845A5041411861 @default.
• W2054504845 hasAuthorship W2054504845A5043073689 @default.
• W2054504845 hasAuthorship W2054504845A5067930144 @default.
• W2054504845 hasBestOaLocation W20545048452 @default.
• W2054504845 hasConcept C104317684 @default.
• W2054504845 hasConcept C139770010 @default.
• W2054504845 hasConcept C153911025 @default.
• W2054504845 hasConcept C170493617 @default.
• W2054504845 hasConcept C2776362946 @default.
• W2054504845 hasConcept C2779438470 @default.
• W2054504845 hasConcept C55493867 @default.
• W2054504845 hasConcept C86339819 @default.
• W2054504845 hasConcept C86803240 @default.
• W2054504845 hasConcept C95444343 @default.
• W2054504845 hasConceptScore W2054504845C104317684 @default.
• W2054504845 hasConceptScore W2054504845C139770010 @default.
• W2054504845 hasConceptScore W2054504845C153911025 @default.
• W2054504845 hasConceptScore W2054504845C170493617 @default.
• W2054504845 hasConceptScore W2054504845C2776362946 @default.

• next