FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054517043> ?p ?o ?g. }

• W2054517043 endingPage "e97149" @default.
• W2054517043 startingPage "e97149" @default.
• W2054517043 abstract "Introduction Observational studies using case-control designs have showed an increased risk of pneumonia associated with inhaled corticosteroid (ICS)-containing medications in patients with chronic obstructive pulmonary disease (COPD). New-user observational cohort designs may minimize biases associated with previous case-control designs. Objective To estimate the association between ICS and pneumonia among new users of ICS relative to inhaled long-acting bronchodilator (LABD) monotherapy. Methods Pneumonia events in COPD patients ≥45 years old were compared among new users of ICS medications (n = 11,555; ICS, ICS/long-acting β2-agonist [LABA] combination) and inhaled LABD monotherapies (n = 6,492; LABA, long-acting muscarinic antagonists) using Cox proportional hazards models, with propensity scores to adjust for confounding. Setting: United Kingdom electronic medical records with linked hospitalization and mortality data (2002–2010). New users were censored at earliest of: pneumonia event, death, changing/discontinuing treatment, or end of follow-up. Outcomes: severe pneumonia (primary) and any pneumonia (secondary). Results Following adjustment, new use of ICS-containing medications was associated with an increased risk of pneumonia hospitalization (n = 322 events; HR = 1.55, 95% CI: 1.14, 2.10) and any pneumonia (n = 702 events; HR = 1.49, 95% CI: 1.22, 1.83). Crude incidence rates of any pneumonia were 48.7 and 30.9 per 1000 person years among the ICS-containing and LABD cohorts, respectively. Excess risk of pneumonia with ICS was reduced when requiring ≥1 month or ≥ 6 months of new use. There was an apparent dose-related effect, with greater risk at higher daily doses of ICS. There was evidence of channeling bias, with more severe patients prescribed ICS, for which the analysis may not have completely adjusted. Conclusions The results of this new-user cohort study are consistent with published findings; ICS were associated with a 20–50% increased risk of pneumonia in COPD, which reduced with exposure time. This risk must be weighed against the benefits when prescribing ICS to patients with COPD." @default.
• W2054517043 created "2016-06-24" @default.
• W2054517043 creator A5009905394 @default.
• W2054517043 creator A5033085096 @default.
• W2054517043 creator A5052397988 @default.
• W2054517043 creator A5075991335 @default.
• W2054517043 creator A5082114306 @default.
• W2054517043 creator A5085023016 @default.
• W2054517043 date "2014-05-30" @default.
• W2054517043 modified "2023-09-26" @default.
• W2054517043 title "Risk of Pneumonia with Inhaled Corticosteroid versus Long-Acting Bronchodilator Regimens in Chronic Obstructive Pulmonary Disease: A New-User Cohort Study" @default.
• W2054517043 cites W131453520 @default.
• W2054517043 cites W1965717335 @default.
• W2054517043 cites W1985359478 @default.
• W2054517043 cites W1995109245 @default.
• W2054517043 cites W2001104945 @default.
• W2054517043 cites W2001727746 @default.
• W2054517043 cites W2003340929 @default.
• W2054517043 cites W2009187570 @default.
• W2054517043 cites W2035481234 @default.
• W2054517043 cites W2035640173 @default.
• W2054517043 cites W2037135054 @default.
• W2054517043 cites W2045545188 @default.
• W2054517043 cites W2047030375 @default.
• W2054517043 cites W2057106704 @default.
• W2054517043 cites W2058823385 @default.
• W2054517043 cites W2060364778 @default.
• W2054517043 cites W2070970673 @default.
• W2054517043 cites W2077672954 @default.
• W2054517043 cites W2080995434 @default.
• W2054517043 cites W2082524772 @default.
• W2054517043 cites W2088789135 @default.
• W2054517043 cites W2088889277 @default.
• W2054517043 cites W2096517093 @default.
• W2054517043 cites W2100738224 @default.
• W2054517043 cites W2107272163 @default.
• W2054517043 cites W2108337616 @default.
• W2054517043 cites W2119069631 @default.
• W2054517043 cites W2120157356 @default.
• W2054517043 cites W2125232214 @default.
• W2054517043 cites W2127104182 @default.
• W2054517043 cites W2133034747 @default.
• W2054517043 cites W2133986277 @default.
• W2054517043 cites W2134492231 @default.
• W2054517043 cites W2139397407 @default.
• W2054517043 cites W2140001959 @default.
• W2054517043 cites W2141924954 @default.
• W2054517043 cites W2145285461 @default.
• W2054517043 cites W2153284508 @default.
• W2054517043 cites W2153810843 @default.
• W2054517043 cites W2164595809 @default.
• W2054517043 cites W2169729194 @default.
• W2054517043 cites W4293874313 @default.
• W2054517043 doi "https://doi.org/10.1371/journal.pone.0097149" @default.
• W2054517043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4039434" @default.
• W2054517043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24878543" @default.
• W2054517043 hasPublicationYear "2014" @default.
• W2054517043 type Work @default.
• W2054517043 sameAs 2054517043 @default.
• W2054517043 citedByCount "39" @default.
• W2054517043 countsByYear W20545170432015 @default.
• W2054517043 countsByYear W20545170432016 @default.
• W2054517043 countsByYear W20545170432017 @default.
• W2054517043 countsByYear W20545170432018 @default.
• W2054517043 countsByYear W20545170432019 @default.
• W2054517043 countsByYear W20545170432020 @default.
• W2054517043 countsByYear W20545170432021 @default.
• W2054517043 countsByYear W20545170432023 @default.
• W2054517043 crossrefType "journal-article" @default.
• W2054517043 hasAuthorship W2054517043A5009905394 @default.
• W2054517043 hasAuthorship W2054517043A5033085096 @default.
• W2054517043 hasAuthorship W2054517043A5052397988 @default.
• W2054517043 hasAuthorship W2054517043A5075991335 @default.
• W2054517043 hasAuthorship W2054517043A5082114306 @default.
• W2054517043 hasAuthorship W2054517043A5085023016 @default.
• W2054517043 hasBestOaLocation W20545170431 @default.
• W2054517043 hasConcept C126322002 @default.
• W2054517043 hasConcept C177713679 @default.
• W2054517043 hasConcept C17923572 @default.
• W2054517043 hasConcept C201903717 @default.
• W2054517043 hasConcept C2776042228 @default.
• W2054517043 hasConcept C2776780178 @default.
• W2054517043 hasConcept C2777914695 @default.
• W2054517043 hasConcept C2781018748 @default.
• W2054517043 hasConcept C50382708 @default.
• W2054517043 hasConcept C71924100 @default.
• W2054517043 hasConcept C72563966 @default.
• W2054517043 hasConcept C77350462 @default.
• W2054517043 hasConceptScore W2054517043C126322002 @default.
• W2054517043 hasConceptScore W2054517043C177713679 @default.
• W2054517043 hasConceptScore W2054517043C17923572 @default.
• W2054517043 hasConceptScore W2054517043C201903717 @default.
• W2054517043 hasConceptScore W2054517043C2776042228 @default.
• W2054517043 hasConceptScore W2054517043C2776780178 @default.
• W2054517043 hasConceptScore W2054517043C2777914695 @default.
• W2054517043 hasConceptScore W2054517043C2781018748 @default.
• W2054517043 hasConceptScore W2054517043C50382708 @default.
• W2054517043 hasConceptScore W2054517043C71924100 @default.

• next