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- W2054517257 abstract "This work presents the highly controlled drug delivery system free from the burst release at an initial stage and equipped with the capability of long term drug release. The nanoporous drug releasing reservoir was combined with porous body resembling cancellous bone. The materials were prepared by the integration of synthesized inorganic hydroxyapatite (HA) and the hybrid gels of bicontinuous sponge-phased L3 silicate and thermo-responsive poly(N-isopropylacrylamide) (L3-PNIPAm gels). The materials were designed to have the three dimensionally interconnected heterogeneous porosity of macro- and mesoporosity, in which the HA has the macroporosity of 150μm to be impregnated the drug into the pores and the L3-PNIPAm gels have mesoporosity of 5 nm to regulate the temperature sensitive drug-release through the pore channels and polymeric network, respectively. Consequently, this bone-mimetic system gave the highly long term drug release over the 60 days without the burst release. The release rate could be controlled with the change of the HA and PNIPAm composition ratios. The structural characterization was achieved by TEM, SEM, XRD, Micro-Raman spectroscopy, BET, and the direct contact cytotoxicity test was also described." @default.
- W2054517257 created "2016-06-24" @default.
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- W2054517257 date "2006-12-27" @default.
- W2054517257 modified "2023-09-23" @default.
- W2054517257 title "Functional bone-mimetic scaffolds of bicontinuous, thermo-responsive L 3 -phase silica/hydroxyapatite nanocomposites" @default.
- W2054517257 doi "https://doi.org/10.1117/12.695985" @default.
- W2054517257 hasPublicationYear "2006" @default.
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