FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054522807> ?p ?o ?g. }

• W2054522807 endingPage "164" @default.
• W2054522807 startingPage "159" @default.
• W2054522807 abstract "Docosahexaenoic acid (DHA) is an n-3 polyunsaturated fatty acid (PUFA) that generally suppresses the function of T lymphocytes and antigen presenting cells (APCs). An emerging mechanism by which DHA modifies lymphocyte function is through changes in the organization of sphingolipid/cholesterol lipid raft membrane domains. Two contradictory models have been proposed to explain how DHA exerts its effects through changes in raft organization. The biophysical model, developed in model membranes, shows that DHA-containing phospholipids form unique non-raft membrane domains, that are organizationally distinct from lipid rafts, which serve to alter the conformation and/or lateral organization of lymphocyte proteins. In contrast, the cellular model on DHA and rafts shows that DHA suppresses lymphocyte function, in part, by directly incorporating into lipid rafts and altering protein activity. To reconcile opposing biophysical and cellular viewpoints, a major revision to existing models is presented herein. Based largely on quantitative microscopy data, it is proposed that DHA, consumed through the diet, modifies lymphocyte function, in part, through the formation of nanometer scale DHA-rich domains. These nano-scale domains disrupt the optimal raft-dependent clustering of proteins necessary for initial signaling. The data covered in this review highlights the importance of understanding how dietary n-3 PUFAs modify lymphocyte membranes, which is essential toward developing these fatty acids as therapeutic agents for treating inflammatory diseases." @default.
• W2054522807 created "2016-06-24" @default.
• W2054522807 creator A5024757186 @default.
• W2054522807 date "2010-04-01" @default.
• W2054522807 modified "2023-10-16" @default.
• W2054522807 title "Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function" @default.
• W2054522807 cites W1562441478 @default.
• W2054522807 cites W1578779604 @default.
• W2054522807 cites W1729366349 @default.
• W2054522807 cites W1761352586 @default.
• W2054522807 cites W1897639093 @default.
• W2054522807 cites W1901952767 @default.
• W2054522807 cites W1904905341 @default.
• W2054522807 cites W1925942814 @default.
• W2054522807 cites W1963728493 @default.
• W2054522807 cites W1978067887 @default.
• W2054522807 cites W1980934355 @default.
• W2054522807 cites W1991186550 @default.
• W2054522807 cites W1993813725 @default.
• W2054522807 cites W1995093903 @default.
• W2054522807 cites W1997036377 @default.
• W2054522807 cites W1997095999 @default.
• W2054522807 cites W2004296371 @default.
• W2054522807 cites W2004313693 @default.
• W2054522807 cites W2008767898 @default.
• W2054522807 cites W2009236385 @default.
• W2054522807 cites W2013804946 @default.
• W2054522807 cites W2015943547 @default.
• W2054522807 cites W2016703718 @default.
• W2054522807 cites W2026578933 @default.
• W2054522807 cites W2027223749 @default.
• W2054522807 cites W2028797559 @default.
• W2054522807 cites W2030560811 @default.
• W2054522807 cites W2032140907 @default.
• W2054522807 cites W2036550812 @default.
• W2054522807 cites W2039969143 @default.
• W2054522807 cites W2042574278 @default.
• W2054522807 cites W2048550135 @default.
• W2054522807 cites W2049334533 @default.
• W2054522807 cites W2049382860 @default.
• W2054522807 cites W2054714399 @default.
• W2054522807 cites W2055227085 @default.
• W2054522807 cites W2080030827 @default.
• W2054522807 cites W2082387724 @default.
• W2054522807 cites W2082987636 @default.
• W2054522807 cites W2090541352 @default.
• W2054522807 cites W2097261471 @default.
• W2054522807 cites W2109225320 @default.
• W2054522807 cites W2111989705 @default.
• W2054522807 cites W2117022351 @default.
• W2054522807 cites W2124035137 @default.
• W2054522807 cites W2130359297 @default.
• W2054522807 cites W2132365435 @default.
• W2054522807 cites W2133956457 @default.
• W2054522807 cites W2139189234 @default.
• W2054522807 cites W2140015079 @default.
• W2054522807 cites W2141764344 @default.
• W2054522807 cites W2144460514 @default.
• W2054522807 cites W2144710665 @default.
• W2054522807 cites W2148607791 @default.
• W2054522807 cites W2154120009 @default.
• W2054522807 cites W2154927241 @default.
• W2054522807 cites W2158603948 @default.
• W2054522807 cites W2160085864 @default.
• W2054522807 cites W2165148465 @default.
• W2054522807 cites W2335314133 @default.
• W2054522807 cites W2413125276 @default.
• W2054522807 cites W4236183098 @default.
• W2054522807 doi "https://doi.org/10.1016/j.plefa.2010.02.026" @default.
• W2054522807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20207118" @default.
• W2054522807 hasPublicationYear "2010" @default.
• W2054522807 type Work @default.
• W2054522807 sameAs 2054522807 @default.
• W2054522807 citedByCount "13" @default.
• W2054522807 countsByYear W20545228072012 @default.
• W2054522807 countsByYear W20545228072013 @default.
• W2054522807 countsByYear W20545228072014 @default.
• W2054522807 countsByYear W20545228072015 @default.
• W2054522807 countsByYear W20545228072020 @default.
• W2054522807 countsByYear W20545228072023 @default.
• W2054522807 crossrefType "journal-article" @default.
• W2054522807 hasAuthorship W2054522807A5024757186 @default.
• W2054522807 hasConcept C14036430 @default.
• W2054522807 hasConcept C15920480 @default.
• W2054522807 hasConcept C178790620 @default.
• W2054522807 hasConcept C185592680 @default.
• W2054522807 hasConcept C19038510 @default.
• W2054522807 hasConcept C203014093 @default.
• W2054522807 hasConcept C2777171753 @default.
• W2054522807 hasConcept C2777761686 @default.
• W2054522807 hasConcept C41625074 @default.
• W2054522807 hasConcept C521977710 @default.
• W2054522807 hasConcept C543025807 @default.
• W2054522807 hasConcept C55493867 @default.
• W2054522807 hasConcept C61705674 @default.
• W2054522807 hasConcept C79266657 @default.
• W2054522807 hasConcept C86803240 @default.
• W2054522807 hasConcept C9132879 @default.

• next