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• W2054523011 abstract "NF-Y is a trimeric transcription factor containing H2A/H2B-like subunits, which specifically binds to the CCAAT box, a common eukaryotic promoter element. To gain insights into NF-Y-dependent transcriptional regulation, we assessed its relationships with positive histone marks by chromatin immunoprecipitation-on-chip and correlative-profiling studies. Unbiased identification of binding sites shows that the majority of genes are bound by NF-Y in the promoter and/or within the coding region. Parallel analysis of H3K9-14ac and H3K4me3 sites indicates that NF-Y loci can be divided in two distinct clusters: (i) a large cohort contains H3K9-14ac and H3K4me3 marks and correlates with expression and (ii) a sizeable group is devoid of these marks and is found on transcriptionally silent genes. Within this class, we find that NF-Y binding is associated with negative histone marks, such as H4K20me3 and H3K27me3. NF-Y removal by a dominant negative NF-YA leads to a decrease in the transcription of expressed genes associated with H3K4me3 and H3K9-14ac, while increasing the levels of many inactive genes. These data indicate that NF-Y is embedded in positive as well as in negative methyl histone marks, serving a dual function in transcriptional regulation, as an activator or as a repressor." @default.
• W2054523011 created "2016-06-24" @default.
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• W2054523011 date "2008-03-01" @default.
• W2054523011 modified "2023-10-16" @default.
• W2054523011 title "The Histone-Like NF-Y Is a Bifunctional Transcription Factor" @default.
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• W2054523011 doi "https://doi.org/10.1128/mcb.01861-07" @default.
• W2054523011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268390" @default.
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