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- W2054533437 abstract "Abstract Viral etiology in human neoplasia is yet to be established but studies of comparative oncology in animals provide a basis for belief that much if not all cancer of man is caused directly or indirectly by viruses, both of DNA and RNA type. It is possible that a portion if not a majority of cancer in man can be prevented by use of viral vaccines, killed or live, such as have already been shown effective in animals, especially Marek's disease of chickens. Studies of vaccines against cancer viruses may proceed with a rich background of prior technology obtained in the development of vaccines against ordinary acute lytic viral infections but it will be essential that current precedents and legal concepts for viral vaccines be altered if progress is to be made. Even though viral etiology in human cancer is unproved, it is timely to conduct conceptual and experimental probes in studies in animal model systems which can be applied to man when the proved cancer viruses are reliably propagated in the laboratory. Perhaps the greatest hurdle in human cancer vaccine development, disallowing an unanticipated breakthrough, will be the establishment of safety and efficacy in a disease in which the incubation period may exceed a half century. Progress toward a vaccine for routine use in man must necessarily, therefore, be reckoned in decades rather than in years. The road to vaccine control may be long and the way may be hard but the benefit should be worth the effort in this disease which is the cause of death in 20% of the population." @default.
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- W2054533437 date "1972-08-01" @default.
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- W2054533437 title "Problems and potentials for human viral cancer vaccines" @default.
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- W2054533437 doi "https://doi.org/10.1016/0091-7435(72)90007-2" @default.
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