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- W2054549649 abstract "Lectins/hemagglutinins are a class of sugar-binding proteins which agglutinate cells and/or precipitate glycoconjugates. They occur widely in plants but manifest significant differences in activities, which means only a few of them own exploitable potentials. The objective of this study was to find and characterize a multifunctional plant lectin with high potential values in food chemistry and medicine. A 60-kDa lectin from Phaseolus vulgaris L. cv. Extralong Autumn Purple Bean (EAPL) was purified by liquid chromatography, and the sequence of its first 20 N-terminal amino acids was ANEIYFSFQRFNETNLILQR. It was galactose-specific and manifested hemagglutinating activity toward erythrocytes of rabbit, rat, mouse, and human ABO blood types. EAPL manifested anti-HIV-1-RT activity, and it could inhibit the proliferation of human tumor cells by inducing the production of apoptotic bodies. The nitric oxide-inducing activity of EAPL may find application in tumor therapy." @default.
- W2054549649 created "2016-06-24" @default.
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- W2054549649 date "2010-01-22" @default.
- W2054549649 modified "2023-10-01" @default.
- W2054549649 title "A Lectin with Anti-HIV-1 Reverse Transcriptase, Antitumor, and Nitric Oxide Inducing Activities from Seeds of <i>Phaseolus vulgaris</i> cv. Extralong Autumn Purple Bean" @default.
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- W2054549649 doi "https://doi.org/10.1021/jf903964u" @default.
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