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- W2054555990 abstract "Since Dodds and his associates1synthesized the estrogenic substance diethylstilbestrol in 1938 numerous clinical studies have demonstrated that this compound is a powerful and therapeutically effective estrogen when administered either by injection or by mouth. Many investigators have shown that it may produce some undesirable reactions. The commonest clinical objection to diethylstilbestrol has been nausea, and in various series from 10 to 60 per cent of the patients treated have complained of this possibly toxic reaction. Usually nausea can be avoided by reducing the dose,2by giving the medication at bedtime,3or by using interrupted treatment.4A few patients do not tolerate even small doses, and Finch5has suggested that nausea may be an allergic reaction. Infrequent occurrence of vomiting, headache, vertigo, abdominal distress, diarrhea or dermatoses has been reported following the administration of diethylstilbestrol. Thus the dosage, and therefore the therapeutic effectiveness, of this" @default.
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- W2054555990 date "1943-10-02" @default.
- W2054555990 modified "2023-09-24" @default.
- W2054555990 title "OCTOFOLLIN, A NEW SYNTHETIC ESTROGEN" @default.
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- W2054555990 doi "https://doi.org/10.1001/jama.1943.02840400009003" @default.
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