FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054556512> ?p ?o ?g. }

• W2054556512 endingPage "29" @default.
• W2054556512 startingPage "19" @default.
• W2054556512 abstract "There are approximately 1.2 million workers exposed to metalworking fluids (MWF), which are used to reduce the heat and friction associated with industrial machining and grinding operations. Irritancy and sensitization potential of 9 National Toxicology Program (NTP) nominated MWFs (TRIM 229, TRIM VX, TRIM SC210, CIMTECH 310, CIMPERIAL 1070, CIMSTAR 3800, SYNTILO 1023, SUPEREDGE 6768, and CLEAREDGE 6584) were examined in a combined local lymph node assay (LLNA). BALB/c mice were dermally exposed to each MWF at concentrations up to 50%. Significant irritation was observed after dermal exposure to all MWFs except CIMTECH 310 and SYNTILO 1023. Of the 9 MWFs, 6 induced greater than a 3-fold increase in lymphocyte proliferation and 7 tested positive in the irritancy assay. TRIM VX yielded the lowest EC3 value (6.9%) with respect to lymphocyte proliferation. Chemical components of TRIM VX identified using HPLC were screened for sensitization potential using structural activity relationship (SAR) modeling and the LLNA. TOPKAT predicted triethanolamine (TEA) as a sensitizer while Derek for Windows predicted only 4-chloro-3-methylphenol (CMP) to be positive for sensitization. When tested in the LLNA only CMP (EC3 = 11.6%) and oleic acid (OA) (EC3 = 29.7%) were identified as sensitizers. Exposure to all tested TRIM VX components resulted in statistically significant irritation. An additive proliferative response was observed when mixtures of the two identified sensitizing TRIM VX components, OA and CMP, were tested in the LLNA. This is one explanation of why the EC3 value of TRIM VX, with respect to lymphocyte proliferation, is lower than those assigned to its sensitizing components." @default.
• W2054556512 created "2016-06-24" @default.
• W2054556512 creator A5003072947 @default.
• W2054556512 creator A5015102283 @default.
• W2054556512 creator A5040023497 @default.
• W2054556512 creator A5043237984 @default.
• W2054556512 creator A5053686544 @default.
• W2054556512 creator A5062428765 @default.
• W2054556512 creator A5063237263 @default.
• W2054556512 creator A5086893064 @default.
• W2054556512 creator A5088401003 @default.
• W2054556512 date "2009-03-01" @default.
• W2054556512 modified "2023-10-09" @default.
• W2054556512 title "Evaluation of irritancy and sensitization potential of metalworking fluid mixtures and components" @default.
• W2054556512 cites W109128850 @default.
• W2054556512 cites W1622165851 @default.
• W2054556512 cites W1866597637 @default.
• W2054556512 cites W1969737221 @default.
• W2054556512 cites W1983695275 @default.
• W2054556512 cites W1984907424 @default.
• W2054556512 cites W2012539891 @default.
• W2054556512 cites W2013525502 @default.
• W2054556512 cites W2017121130 @default.
• W2054556512 cites W2029815838 @default.
• W2054556512 cites W2031249333 @default.
• W2054556512 cites W2053228091 @default.
• W2054556512 cites W2084370633 @default.
• W2054556512 cites W2096685222 @default.
• W2054556512 cites W2108094413 @default.
• W2054556512 cites W2122259325 @default.
• W2054556512 cites W2163251635 @default.
• W2054556512 cites W2170841868 @default.
• W2054556512 cites W2326792534 @default.
• W2054556512 cites W2614696628 @default.
• W2054556512 doi "https://doi.org/10.1080/15476910802604291" @default.
• W2054556512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19519159" @default.
• W2054556512 hasPublicationYear "2009" @default.
• W2054556512 type Work @default.
• W2054556512 sameAs 2054556512 @default.
• W2054556512 citedByCount "15" @default.
• W2054556512 countsByYear W20545565122012 @default.
• W2054556512 countsByYear W20545565122013 @default.
• W2054556512 countsByYear W20545565122014 @default.
• W2054556512 countsByYear W20545565122015 @default.
• W2054556512 countsByYear W20545565122016 @default.
• W2054556512 countsByYear W20545565122017 @default.
• W2054556512 countsByYear W20545565122023 @default.
• W2054556512 crossrefType "journal-article" @default.
• W2054556512 hasAuthorship W2054556512A5003072947 @default.
• W2054556512 hasAuthorship W2054556512A5015102283 @default.
• W2054556512 hasAuthorship W2054556512A5040023497 @default.
• W2054556512 hasAuthorship W2054556512A5043237984 @default.
• W2054556512 hasAuthorship W2054556512A5053686544 @default.
• W2054556512 hasAuthorship W2054556512A5062428765 @default.
• W2054556512 hasAuthorship W2054556512A5063237263 @default.
• W2054556512 hasAuthorship W2054556512A5086893064 @default.
• W2054556512 hasAuthorship W2054556512A5088401003 @default.
• W2054556512 hasConcept C185592680 @default.
• W2054556512 hasConcept C203014093 @default.
• W2054556512 hasConcept C2776217527 @default.
• W2054556512 hasConcept C2777063393 @default.
• W2054556512 hasConcept C2780614586 @default.
• W2054556512 hasConcept C3018346242 @default.
• W2054556512 hasConcept C43617362 @default.
• W2054556512 hasConcept C71924100 @default.
• W2054556512 hasConcept C98274493 @default.
• W2054556512 hasConceptScore W2054556512C185592680 @default.
• W2054556512 hasConceptScore W2054556512C203014093 @default.
• W2054556512 hasConceptScore W2054556512C2776217527 @default.
• W2054556512 hasConceptScore W2054556512C2777063393 @default.
• W2054556512 hasConceptScore W2054556512C2780614586 @default.
• W2054556512 hasConceptScore W2054556512C3018346242 @default.
• W2054556512 hasConceptScore W2054556512C43617362 @default.
• W2054556512 hasConceptScore W2054556512C71924100 @default.
• W2054556512 hasConceptScore W2054556512C98274493 @default.
• W2054556512 hasIssue "1" @default.
• W2054556512 hasLocation W20545565121 @default.
• W2054556512 hasLocation W20545565122 @default.
• W2054556512 hasOpenAccess W2054556512 @default.
• W2054556512 hasPrimaryLocation W20545565121 @default.
• W2054556512 hasRelatedWork W1967355125 @default.
• W2054556512 hasRelatedWork W2034475424 @default.
• W2054556512 hasRelatedWork W2042003251 @default.
• W2054556512 hasRelatedWork W2077969598 @default.
• W2054556512 hasRelatedWork W2296239473 @default.
• W2054556512 hasRelatedWork W2315794829 @default.
• W2054556512 hasRelatedWork W2622251978 @default.
• W2054556512 hasRelatedWork W4255520262 @default.
• W2054556512 hasRelatedWork W4280500035 @default.
• W2054556512 hasRelatedWork W83380756 @default.
• W2054556512 hasVolume "6" @default.
• W2054556512 isParatext "false" @default.
• W2054556512 isRetracted "false" @default.
• W2054556512 magId "2054556512" @default.
• W2054556512 workType "article" @default.