Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054562170> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2054562170 endingPage "265" @default.
- W2054562170 startingPage "259" @default.
- W2054562170 abstract "By understanding the signal transduction pathways through which a cell responds to changes in environmental oxygen levels, we may be able to therapeutically exploit this response by manipulating these pathways.The human adenocarcinoma cell line A549 was exposed to varying durations of hypoxia alone and then plated for survival, or treated with PKC activating agents for 1 h before plating for survival. Western blots were used to determine the kinetics of PKC epsilon and phospholipase C induction.The level of hypoxic killing was directly related to the time of exposure and inversely related to the level of oxygen in the environment. Exposure of the cells to protein kinase C (PKC) activators for 1 h after chronic hypoxic exposure increased cell killing by at least an additional three logs beyond that found for hypoxia alone. Treatment of cells with an inactive phorbol ester 4 alpha-phorbol-12,13-didecanoate (PDA) resulted in no increase in hypoxic cell killing, even at the highest concentrations of PDA which produced no detectable toxicity under normal aerobic conditions. Using inhibitors of phospholipases A2 and C, we were able to completely inhibit the additional hypoxic cell killing induced by TPA, but not the uninduced hypoxic cell killing.These studies suggest that accumulation of phospholipid breakdown products may be responsible for TPA induced cell killing, and that hypoxic cells differ from aerobic cells in their ability to tolerate these products." @default.
- W2054562170 created "2016-06-24" @default.
- W2054562170 creator A5031417959 @default.
- W2054562170 creator A5064520181 @default.
- W2054562170 creator A5071185138 @default.
- W2054562170 creator A5080172191 @default.
- W2054562170 date "1994-05-01" @default.
- W2054562170 modified "2023-09-26" @default.
- W2054562170 title "Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells" @default.
- W2054562170 cites W1541054247 @default.
- W2054562170 cites W1964839077 @default.
- W2054562170 cites W2006894042 @default.
- W2054562170 cites W2009873762 @default.
- W2054562170 cites W2018206895 @default.
- W2054562170 cites W2020795308 @default.
- W2054562170 cites W2021310579 @default.
- W2054562170 cites W2035904165 @default.
- W2054562170 cites W2049088667 @default.
- W2054562170 cites W2055372624 @default.
- W2054562170 cites W2058912647 @default.
- W2054562170 cites W2069372121 @default.
- W2054562170 cites W2086524338 @default.
- W2054562170 cites W2146388445 @default.
- W2054562170 cites W2161439334 @default.
- W2054562170 cites W2164776383 @default.
- W2054562170 cites W2170559897 @default.
- W2054562170 cites W2196524012 @default.
- W2054562170 cites W2254316935 @default.
- W2054562170 doi "https://doi.org/10.1016/0360-3016(94)90272-0" @default.
- W2054562170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8195017" @default.
- W2054562170 hasPublicationYear "1994" @default.
- W2054562170 type Work @default.
- W2054562170 sameAs 2054562170 @default.
- W2054562170 citedByCount "12" @default.
- W2054562170 crossrefType "journal-article" @default.
- W2054562170 hasAuthorship W2054562170A5031417959 @default.
- W2054562170 hasAuthorship W2054562170A5064520181 @default.
- W2054562170 hasAuthorship W2054562170A5071185138 @default.
- W2054562170 hasAuthorship W2054562170A5080172191 @default.
- W2054562170 hasConcept C109316439 @default.
- W2054562170 hasConcept C1491633281 @default.
- W2054562170 hasConcept C178790620 @default.
- W2054562170 hasConcept C184235292 @default.
- W2054562170 hasConcept C185592680 @default.
- W2054562170 hasConcept C195794163 @default.
- W2054562170 hasConcept C202751555 @default.
- W2054562170 hasConcept C2778597717 @default.
- W2054562170 hasConcept C540031477 @default.
- W2054562170 hasConcept C54355233 @default.
- W2054562170 hasConcept C55493867 @default.
- W2054562170 hasConcept C62478195 @default.
- W2054562170 hasConcept C71924100 @default.
- W2054562170 hasConcept C7836513 @default.
- W2054562170 hasConcept C81885089 @default.
- W2054562170 hasConcept C86803240 @default.
- W2054562170 hasConcept C95444343 @default.
- W2054562170 hasConcept C97029542 @default.
- W2054562170 hasConceptScore W2054562170C109316439 @default.
- W2054562170 hasConceptScore W2054562170C1491633281 @default.
- W2054562170 hasConceptScore W2054562170C178790620 @default.
- W2054562170 hasConceptScore W2054562170C184235292 @default.
- W2054562170 hasConceptScore W2054562170C185592680 @default.
- W2054562170 hasConceptScore W2054562170C195794163 @default.
- W2054562170 hasConceptScore W2054562170C202751555 @default.
- W2054562170 hasConceptScore W2054562170C2778597717 @default.
- W2054562170 hasConceptScore W2054562170C540031477 @default.
- W2054562170 hasConceptScore W2054562170C54355233 @default.
- W2054562170 hasConceptScore W2054562170C55493867 @default.
- W2054562170 hasConceptScore W2054562170C62478195 @default.
- W2054562170 hasConceptScore W2054562170C71924100 @default.
- W2054562170 hasConceptScore W2054562170C7836513 @default.
- W2054562170 hasConceptScore W2054562170C81885089 @default.
- W2054562170 hasConceptScore W2054562170C86803240 @default.
- W2054562170 hasConceptScore W2054562170C95444343 @default.
- W2054562170 hasConceptScore W2054562170C97029542 @default.
- W2054562170 hasIssue "2" @default.
- W2054562170 hasLocation W20545621701 @default.
- W2054562170 hasLocation W20545621702 @default.
- W2054562170 hasOpenAccess W2054562170 @default.
- W2054562170 hasPrimaryLocation W20545621701 @default.
- W2054562170 hasRelatedWork W1578197313 @default.
- W2054562170 hasRelatedWork W2004726042 @default.
- W2054562170 hasRelatedWork W2065091962 @default.
- W2054562170 hasRelatedWork W2073187151 @default.
- W2054562170 hasRelatedWork W2086472084 @default.
- W2054562170 hasRelatedWork W2086519667 @default.
- W2054562170 hasRelatedWork W2123013129 @default.
- W2054562170 hasRelatedWork W2423148672 @default.
- W2054562170 hasRelatedWork W4220678905 @default.
- W2054562170 hasRelatedWork W4309341410 @default.
- W2054562170 hasVolume "29" @default.
- W2054562170 isParatext "false" @default.
- W2054562170 isRetracted "false" @default.
- W2054562170 magId "2054562170" @default.
- W2054562170 workType "article" @default.