Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054563722> ?p ?o ?g. }
- W2054563722 endingPage "126" @default.
- W2054563722 startingPage "107" @default.
- W2054563722 abstract "The aim of most metabolism and excretion processes is to remove the drug and drug related material from the body; however, in most cases metabolites are present in abundance in circulation.To allow better in vitro/in vivo correlations a greater understanding of why metabolites formed in organs such as the liver are present in the circulation is necessary.Separating metabolites into highly lipid permeable and low lipid permeable allows the role of passive efflux from the liver and active transport to be dissected.Many drugs form glucuronide metabolites that circulate at high total concentrations and attention is drawn to low lipid permeability, efflux from the liver by MRP3, high plasma protein binding and restricted distribution as the explanation for this.The use of metabolite maps is suggested as a way of displaying complex processes in a simple form." @default.
- W2054563722 created "2016-06-24" @default.
- W2054563722 creator A5002542670 @default.
- W2054563722 creator A5047357717 @default.
- W2054563722 date "2011-11-24" @default.
- W2054563722 modified "2023-10-07" @default.
- W2054563722 title "Why do metabolites circulate?" @default.
- W2054563722 cites W1963517446 @default.
- W2054563722 cites W1970167759 @default.
- W2054563722 cites W1979167419 @default.
- W2054563722 cites W1979456235 @default.
- W2054563722 cites W1981472412 @default.
- W2054563722 cites W1982888645 @default.
- W2054563722 cites W1984613701 @default.
- W2054563722 cites W1991359947 @default.
- W2054563722 cites W1992094155 @default.
- W2054563722 cites W1992809788 @default.
- W2054563722 cites W1994784815 @default.
- W2054563722 cites W1998201688 @default.
- W2054563722 cites W2007776961 @default.
- W2054563722 cites W2010356902 @default.
- W2054563722 cites W2012400732 @default.
- W2054563722 cites W2021845189 @default.
- W2054563722 cites W2028696810 @default.
- W2054563722 cites W2037850814 @default.
- W2054563722 cites W2042740064 @default.
- W2054563722 cites W2048191327 @default.
- W2054563722 cites W2053394164 @default.
- W2054563722 cites W2061699782 @default.
- W2054563722 cites W2065689874 @default.
- W2054563722 cites W2066910350 @default.
- W2054563722 cites W2073885483 @default.
- W2054563722 cites W2075585148 @default.
- W2054563722 cites W2075801836 @default.
- W2054563722 cites W2082929181 @default.
- W2054563722 cites W2099126469 @default.
- W2054563722 cites W2100403878 @default.
- W2054563722 cites W2101686121 @default.
- W2054563722 cites W2104075487 @default.
- W2054563722 cites W2112777963 @default.
- W2054563722 cites W2112820588 @default.
- W2054563722 cites W2115483236 @default.
- W2054563722 cites W2121001657 @default.
- W2054563722 cites W2129832222 @default.
- W2054563722 cites W2130076476 @default.
- W2054563722 cites W2131274993 @default.
- W2054563722 cites W2132859347 @default.
- W2054563722 cites W2138045215 @default.
- W2054563722 cites W2141331332 @default.
- W2054563722 cites W2144438205 @default.
- W2054563722 cites W2150876331 @default.
- W2054563722 cites W2155775136 @default.
- W2054563722 cites W2156214908 @default.
- W2054563722 cites W2159908530 @default.
- W2054563722 cites W2160350843 @default.
- W2054563722 cites W2160923905 @default.
- W2054563722 cites W2161557170 @default.
- W2054563722 cites W2168938059 @default.
- W2054563722 cites W2317224907 @default.
- W2054563722 cites W4255054329 @default.
- W2054563722 doi "https://doi.org/10.3109/00498254.2011.630110" @default.
- W2054563722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22115420" @default.
- W2054563722 hasPublicationYear "2011" @default.
- W2054563722 type Work @default.
- W2054563722 sameAs 2054563722 @default.
- W2054563722 citedByCount "42" @default.
- W2054563722 countsByYear W20545637222012 @default.
- W2054563722 countsByYear W20545637222013 @default.
- W2054563722 countsByYear W20545637222014 @default.
- W2054563722 countsByYear W20545637222015 @default.
- W2054563722 countsByYear W20545637222016 @default.
- W2054563722 countsByYear W20545637222017 @default.
- W2054563722 countsByYear W20545637222018 @default.
- W2054563722 countsByYear W20545637222019 @default.
- W2054563722 countsByYear W20545637222021 @default.
- W2054563722 countsByYear W20545637222022 @default.
- W2054563722 countsByYear W20545637222023 @default.
- W2054563722 crossrefType "journal-article" @default.
- W2054563722 hasAuthorship W2054563722A5002542670 @default.
- W2054563722 hasAuthorship W2054563722A5047357717 @default.
- W2054563722 hasConcept C104317684 @default.
- W2054563722 hasConcept C126322002 @default.
- W2054563722 hasConcept C149011108 @default.
- W2054563722 hasConcept C150903083 @default.
- W2054563722 hasConcept C185592680 @default.
- W2054563722 hasConcept C200082930 @default.
- W2054563722 hasConcept C202751555 @default.
- W2054563722 hasConcept C207001950 @default.
- W2054563722 hasConcept C2776165368 @default.
- W2054563722 hasConcept C2777477808 @default.
- W2054563722 hasConcept C2779186261 @default.
- W2054563722 hasConcept C2780035454 @default.
- W2054563722 hasConcept C4733338 @default.
- W2054563722 hasConcept C55493867 @default.
- W2054563722 hasConcept C62231903 @default.
- W2054563722 hasConcept C71924100 @default.
- W2054563722 hasConcept C86803240 @default.
- W2054563722 hasConcept C89311334 @default.