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- W2054564420 endingPage "252" @default.
- W2054564420 startingPage "237" @default.
- W2054564420 abstract "HSV regulatory proteins VP16 and ICP0 play key roles in launching the lytic program of viral gene expression in most cell types. However, these activation functions are dispensable in U2OS osteosarcoma cells, suggesting that this cell line either expresses an endogenous activator of HSV gene expression or lacks inhibitory mechanisms that are inactivated by VP16 and ICP0 in other cells. To distinguish between these possibilities, we examined the phenotypes of somatic cell hybrids formed between U2OS cells and highly restrictive HEL fibroblasts. The U2OS-HEL heterokarya were as non-permissive as HEL cells, a phenotype that could be overcome by providing either VP16 or ICP0 in trans. Our data indicate that human fibroblasts contain one or more inhibitory factors that act within the nucleus to limit HSV gene expression and argue that VP16 and ICP0 stimulate viral gene expression at least in part by counteracting this innate antiviral defence mechanism." @default.
- W2054564420 created "2016-06-24" @default.
- W2054564420 creator A5008024387 @default.
- W2054564420 creator A5015898479 @default.
- W2054564420 creator A5045996631 @default.
- W2054564420 date "2006-08-01" @default.
- W2054564420 modified "2023-09-29" @default.
- W2054564420 title "Herpes simplex virus regulatory proteins VP16 and ICP0 counteract an innate intranuclear barrier to viral gene expression" @default.
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