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- W2054564838 abstract "Abstract Increased density and altered spatial distribution of subcortical white matter neurons (WMNs) represents one of the more well replicated cellular alterations found in schizophrenia and related disease. In many of the affected cases, the underlying genetic risk architecture for these WMN abnormalities remains unknown. Increased density of neurons immunoreactive for Microtubule‐Associated Protein 2 (MAP2) and Neuronal Nuclear Antigen (NeuN) have been reported by independent studies, though there are negative reports as well; additionally, group differences in some of the studies appear to be driven by a small subset of cases. Alterations in markers for inhibitory (GABAergic) neurons have also been described. For example, downregulation of neuropeptide Y (NPY) and nitric oxide synthase (NOS1) in inhibitory WMN positioned at the gray/white matter border, as well as altered spatial distribution, have been reported. While increased density of WMN has been suggested to reflect disturbance of neurodevelopmental processes, including neuronal migration, neurogenesis, and cell death, alternative hypotheses—such as an adaptive response to microglial activation in mature CNS, as has been described in multiple sclerosis –should also be considered. We argue that larger scale studies involving hundreds of postmortem specimens will be necessary in order to clearly establish the subset of subjects affected. Additionally, these larger cohorts could make it feasible to connect the cellular pathology to environmental and genetic factors implicated in schizophrenia, bipolar disorder, and autism. These could include the 22q11 deletion (Velocardiofacial/DiGeorge) syndrome, which in some cases is associated with neuronal ectopias in white matter." @default.
- W2054564838 created "2016-06-24" @default.
- W2054564838 creator A5025600687 @default.
- W2054564838 creator A5081022384 @default.
- W2054564838 creator A5088545190 @default.
- W2054564838 date "2010-08-04" @default.
- W2054564838 modified "2023-10-02" @default.
- W2054564838 title "White matter neuron alterations in schizophrenia and related disorders" @default.
- W2054564838 cites W1965040374 @default.
- W2054564838 cites W1967443004 @default.
- W2054564838 cites W1968149131 @default.
- W2054564838 cites W1968700646 @default.
- W2054564838 cites W1971847164 @default.
- W2054564838 cites W1972797655 @default.
- W2054564838 cites W1973032194 @default.
- W2054564838 cites W1973333398 @default.
- W2054564838 cites W1975019629 @default.
- W2054564838 cites W1977791488 @default.
- W2054564838 cites W1978238793 @default.
- W2054564838 cites W1979089999 @default.
- W2054564838 cites W1979240985 @default.
- W2054564838 cites W1981718108 @default.
- W2054564838 cites W1981719311 @default.
- W2054564838 cites W1982135531 @default.
- W2054564838 cites W1983651376 @default.
- W2054564838 cites W1984437773 @default.
- W2054564838 cites W1985111805 @default.
- W2054564838 cites W1985400815 @default.
- W2054564838 cites W1988295199 @default.
- W2054564838 cites W1988486070 @default.
- W2054564838 cites W1990060408 @default.
- W2054564838 cites W1991686881 @default.
- W2054564838 cites W1991838363 @default.
- W2054564838 cites W1992073044 @default.
- W2054564838 cites W1994124220 @default.
- W2054564838 cites W1996713100 @default.
- W2054564838 cites W2000894766 @default.
- W2054564838 cites W2001155100 @default.
- W2054564838 cites W2001486260 @default.
- W2054564838 cites W2001555806 @default.
- W2054564838 cites W2002305171 @default.
- W2054564838 cites W2003960093 @default.
- W2054564838 cites W2004547289 @default.
- W2054564838 cites W2004826704 @default.
- W2054564838 cites W2007299780 @default.
- W2054564838 cites W2008682443 @default.
- W2054564838 cites W2009485462 @default.
- W2054564838 cites W2009680012 @default.
- W2054564838 cites W2010230693 @default.
- W2054564838 cites W2011640384 @default.
- W2054564838 cites W2013644296 @default.
- W2054564838 cites W2016717347 @default.
- W2054564838 cites W2020478383 @default.
- W2054564838 cites W2021377987 @default.
- W2054564838 cites W2021399360 @default.
- W2054564838 cites W2022354453 @default.
- W2054564838 cites W2022689127 @default.
- W2054564838 cites W2023368138 @default.
- W2054564838 cites W2023823207 @default.
- W2054564838 cites W2027052321 @default.
- W2054564838 cites W2028107656 @default.
- W2054564838 cites W2028403185 @default.
- W2054564838 cites W2028649540 @default.
- W2054564838 cites W2029437594 @default.
- W2054564838 cites W2031392965 @default.
- W2054564838 cites W2032177799 @default.
- W2054564838 cites W2035319691 @default.
- W2054564838 cites W2036691108 @default.
- W2054564838 cites W2036838270 @default.
- W2054564838 cites W2039996899 @default.
- W2054564838 cites W2044244920 @default.
- W2054564838 cites W2044980193 @default.
- W2054564838 cites W2047347093 @default.
- W2054564838 cites W2050130096 @default.
- W2054564838 cites W2052421461 @default.
- W2054564838 cites W2057565196 @default.
- W2054564838 cites W2060153417 @default.
- W2054564838 cites W2065420555 @default.
- W2054564838 cites W2065825321 @default.
- W2054564838 cites W2069351132 @default.
- W2054564838 cites W2075492585 @default.
- W2054564838 cites W2079310584 @default.
- W2054564838 cites W2083859519 @default.
- W2054564838 cites W2084625484 @default.
- W2054564838 cites W2085450161 @default.
- W2054564838 cites W2085848150 @default.
- W2054564838 cites W2089114713 @default.
- W2054564838 cites W2091527735 @default.
- W2054564838 cites W2092817506 @default.
- W2054564838 cites W2093810348 @default.
- W2054564838 cites W2094660330 @default.
- W2054564838 cites W2094785210 @default.
- W2054564838 cites W2095060637 @default.
- W2054564838 cites W2097760882 @default.
- W2054564838 cites W2098391962 @default.
- W2054564838 cites W2099183732 @default.
- W2054564838 cites W2099626510 @default.
- W2054564838 cites W2100173716 @default.