FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054565869> ?p ?o ?g. }

• W2054565869 endingPage "126" @default.
• W2054565869 startingPage "113" @default.
• W2054565869 abstract "In the present study, we investigated the protective mechanism of quercetin (QUE) and its glycosides, rutin (RUT) and quercitrin (QUI), on reactive oxygen species (ROS)-dependent (H2O2) and -independent (chemical anoxia) cell death in rat glioma C6 cells. Induction of HO-1 protein expression was detected in QUE- but not RUT- or QUI-treated C6 cells, and this was prevented by cycloheximide and actinomycin D. Incubation of C6 cells with QUE, but not RUT or QUI, protected C6 cells from H2O2- and chemical anoxia-induced cytotoxicity according to the MTT and LDH release assays. Apoptotic characteristics including chromatin condensation, DNA ladders, and hypodiploid cells appeared in H2O2-and chemical anoxia-treated C6 cells, and those events were significantly suppressed by adding QUE (but not RUT or QUI). Increases in caspase 3, 8, and 9 enzyme activities with decreases in pro-PARP and pro-caspase 3 protein levels and an increase in cleaved D4-GDI protein were identified in H2O2-and chemical anoxia-treated C6 cells, and these were blocked by the addition of QUE, but not by RUT or QUI. Intracellular peroxide levels increased with H2O2 and decreased with chemical anoxia, and the addition of QUE reduced the intracellular peroxide levels induced by H2O2. Results of an anti-DPPH radical assay showed that QUE, RUT, and QUI dose-dependently inhibited the production of DPPH radicals in vitro; however, QUE (but not RUT or QUI) prevention of DNA damage induced by OH radicals was identified with a plasmid digestion assay. Increases in phosphorylated ERK and p53 protein expressions were detected in H2O2- but not chemical anoxia-treated C6 cells, and the addition of QUE significantly blocked H2O2-induced phosphorylated ERK and p53 protein expressions. Adding the HO-1 inhibitors, SnPP, CoPP, and ZnPP, reversed the protective effect of QUE against H2O2- and chemical anoxia-induced cell death according to the MTT assay and morphological observations. Additionally, QUE exhibited inhibitory effects on LPS/TPA-induced transformation in accordance with a decrease in MMP-9 enzyme activity and iNOS protein expression in C6 cells. Taken together, the results of this study suggest that QUE exhibits an inhibitory effect on both ROS-dependent and -independent cell death, and induction of HO-1 protein expression is involved." @default.
• W2054565869 created "2016-06-24" @default.
• W2054565869 creator A5008294801 @default.
• W2054565869 creator A5029273233 @default.
• W2054565869 creator A5048162579 @default.
• W2054565869 creator A5066505434 @default.
• W2054565869 creator A5069188183 @default.
• W2054565869 date "2006-06-01" @default.
• W2054565869 modified "2023-10-18" @default.
• W2054565869 title "Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells" @default.
• W2054565869 cites W1572769393 @default.
• W2054565869 cites W1791153000 @default.
• W2054565869 cites W1977967715 @default.
• W2054565869 cites W1979308658 @default.
• W2054565869 cites W1981969869 @default.
• W2054565869 cites W1988097355 @default.
• W2054565869 cites W1999965011 @default.
• W2054565869 cites W2003601985 @default.
• W2054565869 cites W2009379812 @default.
• W2054565869 cites W2018627787 @default.
• W2054565869 cites W2018647118 @default.
• W2054565869 cites W2027978523 @default.
• W2054565869 cites W2028582213 @default.
• W2054565869 cites W2033135755 @default.
• W2054565869 cites W2034316664 @default.
• W2054565869 cites W2048545152 @default.
• W2054565869 cites W2049932838 @default.
• W2054565869 cites W2052359737 @default.
• W2054565869 cites W2062532849 @default.
• W2054565869 cites W2071452513 @default.
• W2054565869 cites W2074169655 @default.
• W2054565869 cites W2074545089 @default.
• W2054565869 cites W2074573026 @default.
• W2054565869 cites W2078015631 @default.
• W2054565869 cites W2079457273 @default.
• W2054565869 cites W2093826154 @default.
• W2054565869 cites W2095456713 @default.
• W2054565869 cites W2105234557 @default.
• W2054565869 cites W2107789276 @default.
• W2054565869 cites W2109581010 @default.
• W2054565869 cites W2113248003 @default.
• W2054565869 cites W2119331100 @default.
• W2054565869 cites W2133451731 @default.
• W2054565869 cites W2135767295 @default.
• W2054565869 cites W2143145858 @default.
• W2054565869 cites W2144304323 @default.
• W2054565869 cites W2149789552 @default.
• W2054565869 cites W2172118954 @default.
• W2054565869 cites W2275835282 @default.
• W2054565869 cites W4231042001 @default.
• W2054565869 doi "https://doi.org/10.1016/j.tox.2006.03.007" @default.
• W2054565869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16647178" @default.
• W2054565869 hasPublicationYear "2006" @default.
• W2054565869 type Work @default.
• W2054565869 sameAs 2054565869 @default.
• W2054565869 citedByCount "161" @default.
• W2054565869 countsByYear W20545658692012 @default.
• W2054565869 countsByYear W20545658692013 @default.
• W2054565869 countsByYear W20545658692014 @default.
• W2054565869 countsByYear W20545658692015 @default.
• W2054565869 countsByYear W20545658692016 @default.
• W2054565869 countsByYear W20545658692017 @default.
• W2054565869 countsByYear W20545658692018 @default.
• W2054565869 countsByYear W20545658692019 @default.
• W2054565869 countsByYear W20545658692020 @default.
• W2054565869 countsByYear W20545658692021 @default.
• W2054565869 countsByYear W20545658692022 @default.
• W2054565869 countsByYear W20545658692023 @default.
• W2054565869 crossrefType "journal-article" @default.
• W2054565869 hasAuthorship W2054565869A5008294801 @default.
• W2054565869 hasAuthorship W2054565869A5029273233 @default.
• W2054565869 hasAuthorship W2054565869A5048162579 @default.
• W2054565869 hasAuthorship W2054565869A5066505434 @default.
• W2054565869 hasAuthorship W2054565869A5069188183 @default.
• W2054565869 hasConcept C143425029 @default.
• W2054565869 hasConcept C153911025 @default.
• W2054565869 hasConcept C185592680 @default.
• W2054565869 hasConcept C190283241 @default.
• W2054565869 hasConcept C2777263532 @default.
• W2054565869 hasConcept C2778004101 @default.
• W2054565869 hasConcept C2778128677 @default.
• W2054565869 hasConcept C2781263971 @default.
• W2054565869 hasConcept C3675279 @default.
• W2054565869 hasConcept C48349386 @default.
• W2054565869 hasConcept C552990157 @default.
• W2054565869 hasConcept C55493867 @default.
• W2054565869 hasConcept C79879829 @default.
• W2054565869 hasConcept C86803240 @default.
• W2054565869 hasConceptScore W2054565869C143425029 @default.
• W2054565869 hasConceptScore W2054565869C153911025 @default.
• W2054565869 hasConceptScore W2054565869C185592680 @default.
• W2054565869 hasConceptScore W2054565869C190283241 @default.
• W2054565869 hasConceptScore W2054565869C2777263532 @default.
• W2054565869 hasConceptScore W2054565869C2778004101 @default.
• W2054565869 hasConceptScore W2054565869C2778128677 @default.
• W2054565869 hasConceptScore W2054565869C2781263971 @default.
• W2054565869 hasConceptScore W2054565869C3675279 @default.
• W2054565869 hasConceptScore W2054565869C48349386 @default.

• next