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- W2054567970 abstract "Hb Rouen (α140 (HC2) Tyr→His) is a moderately high oxygen-affinity variant that was found in coincidence with polycythemia vera in a French patient. This hemoglobin provides an example of an alteration of the C-terminus of the α-chain, a region involved in the mechanisms of allosteric regulation. The increase in oxygen-affinity and decrease in cooperativity of this variant is much smaller than that resulting from the same substitution in the β-chain. This model provides additional evidence for the inequivalence between the α- and β-subunits." @default.
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- W2054567970 date "1992-10-01" @default.
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- W2054567970 title "Homoglobin Rouen (α-140 (HC2) Tyr→His): alteration of the α-chain C-terminal region and moderate increase in oxygen affinity" @default.
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- W2054567970 doi "https://doi.org/10.1016/0925-4439(92)90026-j" @default.
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