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- W2054570730 abstract "Significance Our study defines the crucial role of CD14-high bladder cancer (BC) cells in orchestrating multiple hallmarks of cancer in the early stages of BC. Inflammatory factors produced by this subpopulation of tumor cells activate angiogenesis to support establishment and maintenance of an immune-suppressive, inflammatory tumor microenvironment. Additionally, this subpopulation is able to drive tumor growth by producing factors that drive autocrine and paracrine proliferative stimulation. Here we show that a tumor-cell subpopulation establishes a tumor microenvironment orchestrating tumor-promoting inflammation and tumor-cell proliferation. Collectively, this study highlights the need to explore the broader role of CD14-expressing neoplastic cells in other solid tumors. It is noteworthy that CD14 expression is critical for IL6 secretion by these cells. Therefore, therapeutic targeting of CD14 might represent a strategy for treating cancer." @default.
- W2054570730 created "2016-06-24" @default.
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- W2054570730 date "2015-03-30" @default.
- W2054570730 modified "2023-10-14" @default.
- W2054570730 title "CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer" @default.
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- W2054570730 doi "https://doi.org/10.1073/pnas.1424795112" @default.
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