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• W2054570744 abstract "Deletion of the long arm of chromosome 6 (6q) is one of the most common chromosomal abnormalities in human hematological malignancies. Two distinct regions of minimal deletion have been identified by loss of heterozygosity studies at 6q25 to 6q27 (RMD-1) and at 6q21 to 6q23 (RMD-2), suggesting the presence of one or more tumor suppressor genes. We have cloned sequences within RMD-2 and screened for novel genes using a combination of direct sequencing, cDNA library screening, and exon trapping. Sequences generated from a cosmid fragment, mapping within RMD-2, showed homology to theDrosophila taillessgene (tll).The human homologue of theDrosophila taillessgene (humantlx;MGMW-approved symbol, TLX) was subsequently cloned from a fetal brain cDNA library. The gene is a member of the steroid nuclear receptor superfamily and is homologous totllgenes from other species that are involved in brain development.TLXis predominately expressed in the brain and maps to RMD-2 at 6q21 between DNA markersFYNand D6S447, in a YAC clone that also contains marker D6S246. The contributions of this gene to human B-cell leukemia and to brain development are unknown at present." @default.
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• W2054570744 date "1998-05-01" @default.
• W2054570744 modified "2023-10-12" @default.
• W2054570744 title "The Human Homologue of theDrosophila taillessGene (TLX): Characterization and Mapping to a Region of Common Deletion in Human Lymphoid Leukemia on Chromosome 6q21" @default.
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• W2054570744 doi "https://doi.org/10.1006/geno.1998.5270" @default.
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