Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054584647> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2054584647 endingPage "455" @default.
- W2054584647 startingPage "452" @default.
- W2054584647 abstract "The chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 +/- 10 beats/min) was obtained at 3 x 10(-6) mol/l. Reserpine pretreatment, or propranolol 3 x 10(-7) mol/l, or propranolol plus prazosin 10(-6) mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 x 10(-5) mol/l plus cocaine 10(-5) mol/l) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings." @default.
- W2054584647 created "2016-06-24" @default.
- W2054584647 creator A5044857798 @default.
- W2054584647 creator A5065208751 @default.
- W2054584647 creator A5071061476 @default.
- W2054584647 date "1989-10-01" @default.
- W2054584647 modified "2023-10-14" @default.
- W2054584647 title "Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine" @default.
- W2054584647 cites W126330640 @default.
- W2054584647 cites W1975602605 @default.
- W2054584647 cites W1976683973 @default.
- W2054584647 cites W1987468391 @default.
- W2054584647 cites W2012187456 @default.
- W2054584647 cites W2012895667 @default.
- W2054584647 cites W2017103458 @default.
- W2054584647 cites W2033404256 @default.
- W2054584647 cites W2049470080 @default.
- W2054584647 cites W2051684977 @default.
- W2054584647 cites W2068614803 @default.
- W2054584647 cites W2087751453 @default.
- W2054584647 cites W2090488199 @default.
- W2054584647 cites W2092626456 @default.
- W2054584647 cites W2140905677 @default.
- W2054584647 cites W2314142643 @default.
- W2054584647 cites W2398777766 @default.
- W2054584647 cites W2411192673 @default.
- W2054584647 cites W2460935767 @default.
- W2054584647 doi "https://doi.org/10.1007/bf00167048" @default.
- W2054584647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2479845" @default.
- W2054584647 hasPublicationYear "1989" @default.
- W2054584647 type Work @default.
- W2054584647 sameAs 2054584647 @default.
- W2054584647 citedByCount "2" @default.
- W2054584647 crossrefType "journal-article" @default.
- W2054584647 hasAuthorship W2054584647A5044857798 @default.
- W2054584647 hasAuthorship W2054584647A5065208751 @default.
- W2054584647 hasAuthorship W2054584647A5071061476 @default.
- W2054584647 hasBestOaLocation W20545846472 @default.
- W2054584647 hasConcept C126322002 @default.
- W2054584647 hasConcept C134018914 @default.
- W2054584647 hasConcept C158328960 @default.
- W2054584647 hasConcept C170493617 @default.
- W2054584647 hasConcept C185592680 @default.
- W2054584647 hasConcept C2776885963 @default.
- W2054584647 hasConcept C2777842393 @default.
- W2054584647 hasConcept C2777953023 @default.
- W2054584647 hasConcept C2778151854 @default.
- W2054584647 hasConcept C2778514916 @default.
- W2054584647 hasConcept C2780648677 @default.
- W2054584647 hasConcept C2781212610 @default.
- W2054584647 hasConcept C513476851 @default.
- W2054584647 hasConcept C519063684 @default.
- W2054584647 hasConcept C71924100 @default.
- W2054584647 hasConcept C84393581 @default.
- W2054584647 hasConceptScore W2054584647C126322002 @default.
- W2054584647 hasConceptScore W2054584647C134018914 @default.
- W2054584647 hasConceptScore W2054584647C158328960 @default.
- W2054584647 hasConceptScore W2054584647C170493617 @default.
- W2054584647 hasConceptScore W2054584647C185592680 @default.
- W2054584647 hasConceptScore W2054584647C2776885963 @default.
- W2054584647 hasConceptScore W2054584647C2777842393 @default.
- W2054584647 hasConceptScore W2054584647C2777953023 @default.
- W2054584647 hasConceptScore W2054584647C2778151854 @default.
- W2054584647 hasConceptScore W2054584647C2778514916 @default.
- W2054584647 hasConceptScore W2054584647C2780648677 @default.
- W2054584647 hasConceptScore W2054584647C2781212610 @default.
- W2054584647 hasConceptScore W2054584647C513476851 @default.
- W2054584647 hasConceptScore W2054584647C519063684 @default.
- W2054584647 hasConceptScore W2054584647C71924100 @default.
- W2054584647 hasConceptScore W2054584647C84393581 @default.
- W2054584647 hasIssue "4" @default.
- W2054584647 hasLocation W20545846471 @default.
- W2054584647 hasLocation W20545846472 @default.
- W2054584647 hasLocation W20545846473 @default.
- W2054584647 hasOpenAccess W2054584647 @default.
- W2054584647 hasPrimaryLocation W20545846471 @default.
- W2054584647 hasRelatedWork W1983321239 @default.
- W2054584647 hasRelatedWork W1984541950 @default.
- W2054584647 hasRelatedWork W2022857682 @default.
- W2054584647 hasRelatedWork W2054584647 @default.
- W2054584647 hasRelatedWork W2061201600 @default.
- W2054584647 hasRelatedWork W2070458112 @default.
- W2054584647 hasRelatedWork W2272330384 @default.
- W2054584647 hasRelatedWork W2411309162 @default.
- W2054584647 hasRelatedWork W2471844866 @default.
- W2054584647 hasRelatedWork W4366741334 @default.
- W2054584647 hasVolume "340" @default.
- W2054584647 isParatext "false" @default.
- W2054584647 isRetracted "false" @default.
- W2054584647 magId "2054584647" @default.
- W2054584647 workType "article" @default.