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- W2054597029 abstract "To the Editor: We read with great interest the recent article by Oppenheim and colleagues.1 The authors reported a small, retrospective series of 28 patients at high risk of developing malignant middle cerebral artery (MCA) infarction and identified quantitative volume measurement of diffusion-weighted imaging (DWI) ischemic hyperintensity as a reliable tool to predict malignant MCA infarction.Ischemic cerebral infarction associated with extensive edema and marked elevation of intracranial pressure may cause ischemia of neighboring brain tissue and thus lead to further infarction.2 Decompressive craniectomy may interrupt this vicious cycle by decreasing intracranial pressure. This may increase cerebral perfusion pressure and optimize retrograde perfusion of MCA branches via leptomeningeal collaterals; functionally compromised but viable brain may thus be able to survive.3 The clinical4 and our experimental5 6 7 results indicate that decompressive craniectomy for space-occupying cerebral ischemia not only reduces mortality but also significantly improves outcome and reduces infarction size, especially when performed very early after vessel occlusion. MR studies revealed …" @default.
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- W2054597029 date "2001-03-01" @default.
- W2054597029 modified "2023-09-25" @default.
- W2054597029 title "Decompressive Craniectomy for Early Therapy and Secondary Prevention of Cerebral Infarction" @default.
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- W2054597029 doi "https://doi.org/10.1161/01.str.32.3.813" @default.
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