FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054597807> ?p ?o ?g. }

• W2054597807 abstract "Φ-value analysis has proved to be a powerful technique in protein folding studies. It has been used to study the transition state structures, to infer microscopic folding pathways, and to identify key residues in the protein folding process. However, its effectiveness in protein binding reaction has not been tested, especially when a fly-casting mechanism is involved. In this article we attempt to answer this question through a coarse-grained study of the binding reaction of Arc repressor dimer. Our simulations show that its binding process proceeds through a fly-casting mechanism, consistent with previous results. We then estimate the importance of the residues for the fly-casting binding by computationally mutating each of them into glycine and calculating their respective effects on the capture radius. It is found that (1) the residues with high Φ values may not be responsible for the large capture radius in the fly-casting binding; (2) mutation of residues with low Φ values may destabilize the denatured states and then increase the capture radius, presumably further increasing the binding rate. Based on our simulations, we conclude that Φ values do not reflect well the importance of residues in the fly-casting binding reaction and need to be combined with other techniques to provide a complete picture." @default.
• W2054597807 created "2016-06-24" @default.
• W2054597807 creator A5017894910 @default.
• W2054597807 creator A5038902147 @default.
• W2054597807 creator A5042241049 @default.
• W2054597807 creator A5046597133 @default.
• W2054597807 creator A5091265780 @default.
• W2054597807 date "2011-07-14" @default.
• W2054597807 modified "2023-09-23" @default.
• W2054597807 title "Effectiveness ofΦ-value analysis in the binding process of Arc repressor dimer" @default.
• W2054597807 cites W1530641120 @default.
• W2054597807 cites W1536428180 @default.
• W2054597807 cites W1606187419 @default.
• W2054597807 cites W1829960224 @default.
• W2054597807 cites W1964758803 @default.
• W2054597807 cites W1992787746 @default.
• W2054597807 cites W1993177346 @default.
• W2054597807 cites W2000149219 @default.
• W2054597807 cites W2006192061 @default.
• W2054597807 cites W2010004274 @default.
• W2054597807 cites W2013593586 @default.
• W2054597807 cites W2020913247 @default.
• W2054597807 cites W2023231003 @default.
• W2054597807 cites W2027384625 @default.
• W2054597807 cites W2034299708 @default.
• W2054597807 cites W2042041233 @default.
• W2054597807 cites W2051039246 @default.
• W2054597807 cites W2052606462 @default.
• W2054597807 cites W2053960740 @default.
• W2054597807 cites W2056617446 @default.
• W2054597807 cites W2065864578 @default.
• W2054597807 cites W2068538909 @default.
• W2054597807 cites W2077761730 @default.
• W2054597807 cites W2083174976 @default.
• W2054597807 cites W2112154906 @default.
• W2054597807 cites W2115273980 @default.
• W2054597807 cites W2141509162 @default.
• W2054597807 cites W2160480536 @default.
• W2054597807 doi "https://doi.org/10.1103/physreve.84.011909" @default.
• W2054597807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21867215" @default.
• W2054597807 hasPublicationYear "2011" @default.
• W2054597807 type Work @default.
• W2054597807 sameAs 2054597807 @default.
• W2054597807 citedByCount "5" @default.
• W2054597807 countsByYear W20545978072014 @default.
• W2054597807 countsByYear W20545978072016 @default.
• W2054597807 countsByYear W20545978072018 @default.
• W2054597807 countsByYear W20545978072021 @default.
• W2054597807 crossrefType "journal-article" @default.
• W2054597807 hasAuthorship W2054597807A5017894910 @default.
• W2054597807 hasAuthorship W2054597807A5038902147 @default.
• W2054597807 hasAuthorship W2054597807A5042241049 @default.
• W2054597807 hasAuthorship W2054597807A5046597133 @default.
• W2054597807 hasAuthorship W2054597807A5091265780 @default.
• W2054597807 hasConcept C104317684 @default.
• W2054597807 hasConcept C107824862 @default.
• W2054597807 hasConcept C111919701 @default.
• W2054597807 hasConcept C121332964 @default.
• W2054597807 hasConcept C12554922 @default.
• W2054597807 hasConcept C127413603 @default.
• W2054597807 hasConcept C158448853 @default.
• W2054597807 hasConcept C159467904 @default.
• W2054597807 hasConcept C178635117 @default.
• W2054597807 hasConcept C178790620 @default.
• W2054597807 hasConcept C184779094 @default.
• W2054597807 hasConcept C185592680 @default.
• W2054597807 hasConcept C192562407 @default.
• W2054597807 hasConcept C2776545253 @default.
• W2054597807 hasConcept C2779546866 @default.
• W2054597807 hasConcept C2781020372 @default.
• W2054597807 hasConcept C38652104 @default.
• W2054597807 hasConcept C41008148 @default.
• W2054597807 hasConcept C55493867 @default.
• W2054597807 hasConcept C78519656 @default.
• W2054597807 hasConcept C8010536 @default.
• W2054597807 hasConcept C86339819 @default.
• W2054597807 hasConcept C86803240 @default.
• W2054597807 hasConcept C93282013 @default.
• W2054597807 hasConceptScore W2054597807C104317684 @default.
• W2054597807 hasConceptScore W2054597807C107824862 @default.
• W2054597807 hasConceptScore W2054597807C111919701 @default.
• W2054597807 hasConceptScore W2054597807C121332964 @default.
• W2054597807 hasConceptScore W2054597807C12554922 @default.
• W2054597807 hasConceptScore W2054597807C127413603 @default.
• W2054597807 hasConceptScore W2054597807C158448853 @default.
• W2054597807 hasConceptScore W2054597807C159467904 @default.
• W2054597807 hasConceptScore W2054597807C178635117 @default.
• W2054597807 hasConceptScore W2054597807C178790620 @default.
• W2054597807 hasConceptScore W2054597807C184779094 @default.
• W2054597807 hasConceptScore W2054597807C185592680 @default.
• W2054597807 hasConceptScore W2054597807C192562407 @default.
• W2054597807 hasConceptScore W2054597807C2776545253 @default.
• W2054597807 hasConceptScore W2054597807C2779546866 @default.
• W2054597807 hasConceptScore W2054597807C2781020372 @default.
• W2054597807 hasConceptScore W2054597807C38652104 @default.
• W2054597807 hasConceptScore W2054597807C41008148 @default.
• W2054597807 hasConceptScore W2054597807C55493867 @default.
• W2054597807 hasConceptScore W2054597807C78519656 @default.
• W2054597807 hasConceptScore W2054597807C8010536 @default.
• W2054597807 hasConceptScore W2054597807C86339819 @default.

• next