Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054605754> ?p ?o ?g. }
- W2054605754 endingPage "372" @default.
- W2054605754 startingPage "365" @default.
- W2054605754 abstract "The non-structural protein 1 (NS1) of avian influenza virus was defined as one of the virulent factors. To understand the effect of NS1 protein of influenza virus H5N1 isolated in Thailand on type I (α/β) interferon (IFN) synthesis, five reverse genetic viruses were constructed and used as models. The viruses were generated using NS genomic segment from A/Peurto Rico/8/1934 (H1N1) and four avian influenza viruses isolated from the first outbreak in Thailand. All the viruses have the rest of the genome from A/Peurto Rico/8/1934 (H1N1). The constructed viruses were named (1) NS1 PR8/34, (2) NS1 wild type, (3) NS1 L15FD53G, (4) NS1 N171I and (5) NS1 E71K, respectively. The type I (α/β) IFN gene expression in control and infected primary chicken embryonic fibroblast cells were analyzed by quantitative polymerase chain reaction. The results show that the inhibition of IFN-β gene expression by NS1 wild type infected cells is stronger than NS1 N171I, NS1 E71K, NS1 PR8/34 and NS1 L15FD53G, respectively. The data suggest that the difference of amino acid sequence of NS1 protein contributes to the IFN-β antagonist. In contrast, the difference of the NS1 protein does not influence in the IFN-α antagonistic activity." @default.
- W2054605754 created "2016-06-24" @default.
- W2054605754 creator A5009074250 @default.
- W2054605754 creator A5011834834 @default.
- W2054605754 creator A5014561083 @default.
- W2054605754 creator A5024540382 @default.
- W2054605754 creator A5029770588 @default.
- W2054605754 creator A5049317513 @default.
- W2054605754 creator A5051268804 @default.
- W2054605754 creator A5068783140 @default.
- W2054605754 creator A5072701485 @default.
- W2054605754 date "2013-08-28" @default.
- W2054605754 modified "2023-10-01" @default.
- W2054605754 title "Changes in the NS1 gene of avian influenza viruses isolated in Thailand affect expression of type I interferon in primary chicken embryonic fibroblast cells" @default.
- W2054605754 cites W1966807407 @default.
- W2054605754 cites W1968796194 @default.
- W2054605754 cites W1978356033 @default.
- W2054605754 cites W1991297120 @default.
- W2054605754 cites W1994899977 @default.
- W2054605754 cites W1995616397 @default.
- W2054605754 cites W2012362209 @default.
- W2054605754 cites W2019815517 @default.
- W2054605754 cites W2024994988 @default.
- W2054605754 cites W2034649150 @default.
- W2054605754 cites W2056080643 @default.
- W2054605754 cites W2083437974 @default.
- W2054605754 cites W2091527885 @default.
- W2054605754 cites W2093983981 @default.
- W2054605754 cites W2099249565 @default.
- W2054605754 cites W2107277218 @default.
- W2054605754 cites W2108358599 @default.
- W2054605754 cites W2110214166 @default.
- W2054605754 cites W2111899185 @default.
- W2054605754 cites W2124284032 @default.
- W2054605754 cites W2129148489 @default.
- W2054605754 cites W2135187368 @default.
- W2054605754 cites W2150403537 @default.
- W2054605754 cites W2153782171 @default.
- W2054605754 cites W2154487982 @default.
- W2054605754 cites W2159889668 @default.
- W2054605754 cites W4252527896 @default.
- W2054605754 doi "https://doi.org/10.1007/s13337-013-0158-8" @default.
- W2054605754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3832696" @default.
- W2054605754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24426299" @default.
- W2054605754 hasPublicationYear "2013" @default.
- W2054605754 type Work @default.
- W2054605754 sameAs 2054605754 @default.
- W2054605754 citedByCount "4" @default.
- W2054605754 countsByYear W20546057542017 @default.
- W2054605754 countsByYear W20546057542019 @default.
- W2054605754 countsByYear W20546057542022 @default.
- W2054605754 countsByYear W20546057542023 @default.
- W2054605754 crossrefType "journal-article" @default.
- W2054605754 hasAuthorship W2054605754A5009074250 @default.
- W2054605754 hasAuthorship W2054605754A5011834834 @default.
- W2054605754 hasAuthorship W2054605754A5014561083 @default.
- W2054605754 hasAuthorship W2054605754A5024540382 @default.
- W2054605754 hasAuthorship W2054605754A5029770588 @default.
- W2054605754 hasAuthorship W2054605754A5049317513 @default.
- W2054605754 hasAuthorship W2054605754A5051268804 @default.
- W2054605754 hasAuthorship W2054605754A5068783140 @default.
- W2054605754 hasAuthorship W2054605754A5072701485 @default.
- W2054605754 hasBestOaLocation W20546057542 @default.
- W2054605754 hasConcept C104317684 @default.
- W2054605754 hasConcept C141231307 @default.
- W2054605754 hasConcept C145103041 @default.
- W2054605754 hasConcept C153911025 @default.
- W2054605754 hasConcept C159047783 @default.
- W2054605754 hasConcept C2522874641 @default.
- W2054605754 hasConcept C2776178377 @default.
- W2054605754 hasConcept C2777546802 @default.
- W2054605754 hasConcept C2780381497 @default.
- W2054605754 hasConcept C519248777 @default.
- W2054605754 hasConcept C54355233 @default.
- W2054605754 hasConcept C60987743 @default.
- W2054605754 hasConcept C81885089 @default.
- W2054605754 hasConcept C86803240 @default.
- W2054605754 hasConcept C89423630 @default.
- W2054605754 hasConceptScore W2054605754C104317684 @default.
- W2054605754 hasConceptScore W2054605754C141231307 @default.
- W2054605754 hasConceptScore W2054605754C145103041 @default.
- W2054605754 hasConceptScore W2054605754C153911025 @default.
- W2054605754 hasConceptScore W2054605754C159047783 @default.
- W2054605754 hasConceptScore W2054605754C2522874641 @default.
- W2054605754 hasConceptScore W2054605754C2776178377 @default.
- W2054605754 hasConceptScore W2054605754C2777546802 @default.
- W2054605754 hasConceptScore W2054605754C2780381497 @default.
- W2054605754 hasConceptScore W2054605754C519248777 @default.
- W2054605754 hasConceptScore W2054605754C54355233 @default.
- W2054605754 hasConceptScore W2054605754C60987743 @default.
- W2054605754 hasConceptScore W2054605754C81885089 @default.
- W2054605754 hasConceptScore W2054605754C86803240 @default.
- W2054605754 hasConceptScore W2054605754C89423630 @default.
- W2054605754 hasIssue "3" @default.
- W2054605754 hasLocation W20546057541 @default.
- W2054605754 hasLocation W20546057542 @default.
- W2054605754 hasLocation W20546057543 @default.
- W2054605754 hasLocation W20546057544 @default.