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- W2054606441 abstract "Significance The bacterium Pseudomonas aeruginosa is an opportunistic pathogen of humans and is the leading cause of death in patients with cystic fibrosis (CF). We sequenced the genomes of P. aeruginosa isolated from respiratory tracts of patients with CF to investigate general patterns of adaptation associated with chronic infection. Selection imposed by the CF lung environment has had a major influence on genomic evolution and the genetic characteristics of isolates causing contemporary infection. Many of the genes and pathways implicated in adaptive evolution within the host had obvious roles in the pathogenic lifestyle of this bacteria. Genome sequence data indicated that an epidemic strain, with increased virulence and multidrug resistance, has spread between clinics in the United Kingdom and North America." @default.
- W2054606441 created "2016-06-24" @default.
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- W2054606441 date "2013-12-09" @default.
- W2054606441 modified "2023-09-26" @default.
- W2054606441 title "Evolutionary genomics of epidemic and nonepidemic strains of <i>Pseudomonas aeruginosa</i>" @default.
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- W2054606441 doi "https://doi.org/10.1073/pnas.1307862110" @default.
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