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- W2054608022 abstract "These studies were performed to evaluate the effect of 2-aminoethoxydiphenyl borate (2-APB), a novel membrane-permeable inositol 1,4,5-trisphosphate-receptor inhibitor on agonist-induced, spontaneous, and KCl-stimulated in vitro myometrial contractions. 2-APB significantly inhibited spontaneous myometrial contractions as well as phasic contractions induced by various uterotonic agonists. Confiriming its effects on intracellular calcium release, 2-APB inhibited phasic contractions in the absence of extracellular calcium. 2-APB had little effect on the tonic response to KCl stimulation, implicating its insignificant effect on voltage-gated calcium channels. The inhibitory effect of 2-APB on phasic contractions was completely reversed by washout. In summary, 2-APB effectively penetrated uterine tissue and significantly inhibited myometrial events previously shown to be mediated through activation of the PI-signaling pathway." @default.
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- W2054608022 date "1999-11-01" @default.
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- W2054608022 title "The Effects of 2-Aminoethoxydiphenyl Borate, a Novel Inositol 1,4,5-Trisphosphate Receptor Modulator on Myometrial Contractions" @default.
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- W2054608022 doi "https://doi.org/10.1006/bbrc.1999.1602" @default.
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