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• W2054610414 abstract "OBJECTIVE: The purpose of this study was to measure cord blood endothelin-1,2 concentrations in growth-restricted infants with abnormal flow velocity waveforms. STUDY DESIGN: Endothelin-1,2 concentrations were measured by radioimmunoassay in the cord blood of 16 growth-restricted infants with abnormal flow velocity waveforms before delivery, 16 growth-restricted infants with normal flow velocity waveforms before delivery, and 44 appropriately grown infants. Clinical data regarding pregnancy complications and neonatal outcome were collected. RESULTS: The mean endothelin-1,2 concentration in growth-restricted infants with abnormal flow velocity waveforms (50.2 ± 16.4 pg/ml) was significantly higher than in growth-restricted infants with normal flow velocity waveforms (33.3 ± 14.2 pg/ml, p < 0.05) or in appropriately grown infants (25.8 ± 9.7 pg/ml, p < 0.05). Oligohydramnios was also associated with elevated endothelin levels. CONCLUSION: We conclude that endothelin-1,2 concentrations are elevated in growth-restricted infants with abnormal flow velocity waveforms and may play a role in the development of abnormal fetoplacental resistance. (AM J OBSTET GYNECOL 1996;174:1599-604.)" @default.
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• W2054610414 date "1996-05-01" @default.
• W2054610414 modified "2023-10-18" @default.
• W2054610414 title "Elevated endothelin levels are associated with increased placental resistance" @default.
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• W2054610414 doi "https://doi.org/10.1016/s0002-9378(96)70613-0" @default.
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