FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054636611> ?p ?o ?g. }

• W2054636611 endingPage "543" @default.
• W2054636611 startingPage "527" @default.
• W2054636611 abstract "The α1 connexin (connexin43) is regarded as the major gap junction protein of the myocardium because it predominates there in mammals. Here, we show that it is not the major connexin of the working myocardium in non‐mammalian vertebrates, which instead express β1‐like connexins homologous to mammalian connexin32. A phylogenetic series of hearts was immunostained with seven antibodies raised against peptide sequences specific for three distinct members of the gap junction connexin family: α1, β1 and α5 (mammalian connexin40/avian connexin42). Working myocardium from two ascidian chordates (Ciona and Mogula), a teleost (Carassius), a frog (Xenopus) and two reptiles (Anolis and Alligator) was found to express a β1‐like connexin, rather than an α1‐like connexin. An α1‐like connexin was nevertheless often detected in other cardiac tissues. In the chicken (by ancestry a reptile), the developing myocardium expressed a β1‐like connexin strongly on embryonic day 6 but less strongly at hatching, and minimally in the adult. Myocardial expression of α5 connexin increased during development, but remained strongest in the coronary vascular endothelial and cardiac conduction tissues. The arteriolar smooth muscle of the chicken expressed α1 connexin throughout development, but its myocardium did not. In contrast, the working myocardium of a marsupial mammal (the opossum Trichosurus ) strongly expressed an α1 connexin just like placental mammals. These results imply that a shift from β1 to α1 connexin expression in the heart occurred prior to the evolution of the opossums. The β and α connexin subfamilies have different permeabilities and gating properties, and we discuss factors that might have made this shift beneficial." @default.
• W2054636611 created "2016-06-24" @default.
• W2054636611 creator A5016255536 @default.
• W2054636611 creator A5024860240 @default.
• W2054636611 creator A5048589412 @default.
• W2054636611 creator A5074313707 @default.
• W2054636611 creator A5087884339 @default.
• W2054636611 date "1998-07-01" @default.
• W2054636611 modified "2023-10-16" @default.
• W2054636611 title "EXPRESSION OF MAJOR GAP JUNCTION CONNEXIN TYPES IN THE WORKING MYOCARDIUM OF EIGHT CHORDATES" @default.
• W2054636611 cites W1588494452 @default.
• W2054636611 cites W1592198449 @default.
• W2054636611 cites W1866331480 @default.
• W2054636611 cites W1973346248 @default.
• W2054636611 cites W1981321665 @default.
• W2054636611 cites W1983712628 @default.
• W2054636611 cites W1984335129 @default.
• W2054636611 cites W2009255698 @default.
• W2054636611 cites W2020810177 @default.
• W2054636611 cites W2033215167 @default.
• W2054636611 cites W2035618489 @default.
• W2054636611 cites W2048537844 @default.
• W2054636611 cites W2061141141 @default.
• W2054636611 cites W2063801792 @default.
• W2054636611 cites W2069035576 @default.
• W2054636611 cites W2070349643 @default.
• W2054636611 cites W2075500496 @default.
• W2054636611 cites W2077660651 @default.
• W2054636611 cites W2081952897 @default.
• W2054636611 cites W2084282904 @default.
• W2054636611 cites W2085965780 @default.
• W2054636611 cites W2087868231 @default.
• W2054636611 cites W2090288859 @default.
• W2054636611 cites W2098872610 @default.
• W2054636611 cites W2110878857 @default.
• W2054636611 cites W2111817213 @default.
• W2054636611 cites W2116627382 @default.
• W2054636611 cites W2134812217 @default.
• W2054636611 cites W2155414396 @default.
• W2054636611 cites W2170071603 @default.
• W2054636611 cites W2277597417 @default.
• W2054636611 cites W2292963720 @default.
• W2054636611 cites W2336012023 @default.
• W2054636611 cites W2412688410 @default.
• W2054636611 cites W2436605355 @default.
• W2054636611 doi "https://doi.org/10.1006/cbir.1998.0295" @default.
• W2054636611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10452821" @default.
• W2054636611 hasPublicationYear "1998" @default.
• W2054636611 type Work @default.
• W2054636611 sameAs 2054636611 @default.
• W2054636611 citedByCount "38" @default.
• W2054636611 countsByYear W20546366112012 @default.
• W2054636611 countsByYear W20546366112014 @default.
• W2054636611 countsByYear W20546366112015 @default.
• W2054636611 countsByYear W20546366112018 @default.
• W2054636611 countsByYear W20546366112019 @default.
• W2054636611 countsByYear W20546366112020 @default.
• W2054636611 countsByYear W20546366112021 @default.
• W2054636611 crossrefType "journal-article" @default.
• W2054636611 hasAuthorship W2054636611A5016255536 @default.
• W2054636611 hasAuthorship W2054636611A5024860240 @default.
• W2054636611 hasAuthorship W2054636611A5048589412 @default.
• W2054636611 hasAuthorship W2054636611A5074313707 @default.
• W2054636611 hasAuthorship W2054636611A5087884339 @default.
• W2054636611 hasConcept C104317684 @default.
• W2054636611 hasConcept C105702510 @default.
• W2054636611 hasConcept C145103041 @default.
• W2054636611 hasConcept C158157758 @default.
• W2054636611 hasConcept C2779535977 @default.
• W2054636611 hasConcept C2780228694 @default.
• W2054636611 hasConcept C54355233 @default.
• W2054636611 hasConcept C62425271 @default.
• W2054636611 hasConcept C79879829 @default.
• W2054636611 hasConcept C86803240 @default.
• W2054636611 hasConcept C95444343 @default.
• W2054636611 hasConceptScore W2054636611C104317684 @default.
• W2054636611 hasConceptScore W2054636611C105702510 @default.
• W2054636611 hasConceptScore W2054636611C145103041 @default.
• W2054636611 hasConceptScore W2054636611C158157758 @default.
• W2054636611 hasConceptScore W2054636611C2779535977 @default.
• W2054636611 hasConceptScore W2054636611C2780228694 @default.
• W2054636611 hasConceptScore W2054636611C54355233 @default.
• W2054636611 hasConceptScore W2054636611C62425271 @default.
• W2054636611 hasConceptScore W2054636611C79879829 @default.
• W2054636611 hasConceptScore W2054636611C86803240 @default.
• W2054636611 hasConceptScore W2054636611C95444343 @default.
• W2054636611 hasIssue "7-8" @default.
• W2054636611 hasLocation W20546366111 @default.
• W2054636611 hasLocation W20546366112 @default.
• W2054636611 hasOpenAccess W2054636611 @default.
• W2054636611 hasPrimaryLocation W20546366111 @default.
• W2054636611 hasRelatedWork W1744239203 @default.
• W2054636611 hasRelatedWork W1989127634 @default.
• W2054636611 hasRelatedWork W1996470658 @default.
• W2054636611 hasRelatedWork W2040850663 @default.
• W2054636611 hasRelatedWork W2048275409 @default.
• W2054636611 hasRelatedWork W2050127546 @default.
• W2054636611 hasRelatedWork W2078261885 @default.

• next