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• W2054643398 startingPage "e329" @default.
• W2054643398 abstract "Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein-protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient's risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions." @default.
• W2054643398 created "2016-06-24" @default.
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• W2054643398 date "2013-12-03" @default.
• W2054643398 modified "2023-10-17" @default.
• W2054643398 title "Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes" @default.
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• W2054643398 doi "https://doi.org/10.1038/tp.2013.108" @default.
• W2054643398 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4030327" @default.
• W2054643398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24301647" @default.
• W2054643398 hasPublicationYear "2013" @default.
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