FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054652476> ?p ?o ?g. }

• W2054652476 endingPage "1571" @default.
• W2054652476 startingPage "1566" @default.
• W2054652476 abstract "The aim of this phase I study was to establish the maximum tolerated dose (MTD) of 5-fluorouracil (5-FU), administered as a 5-day chronomodulated infusion in combination with 1-folinic acid (FA) to ambulatory metastatic colorectal cancer patients. Consecutive cohorts of 6 patients were given 5-FU and FA infusions from 10.00 p.m. to 10.00 a.m. with peak delivery at 4.00 a.m. by means of a multichannel programmable pump. The FA dose was always the same (150 mg/m2/d). For the first cohort, the 5-FU dose level was 600 mg/m2/d at the first course, escalated by 100 mg/m2 for each subsequent cohort. Intrapatient dose was also escalated by 100 mg/m2 if toxicity was less than grade 2. The courses were repeated every 3 weeks. Thirty-four patients (17 previously treated) received a total of 154 courses. Dose-limiting toxicity consisted of stomatitis and diarrhoea. No significant haematological, cutaneous or cardiac toxicity was encountered. The MTD of 5-FU was reached at the fourth level (first course at 900 mg/m2/d equal to 4500 mg/m2/course) with 5-FU increased to 1100 mg/m2/d (5500 mg/m2/course) in 4 patients. The received 5-FU dose intensity (DI) over the first 3 courses at this level was 1318 mg/m2/week. Thirty-three patients were assessed for response. An objective response was achieved in 1 out of the 13 previously-treated and in 8 out of the 20 previously-untreated patients. The chronomodulated infusion of 5-FU at a dose of 900 mg/m2/d, together with FA at 150 mg/m2/d for 5 days, was safely delivered to out-patients with metastatic colorectal cancer. The low toxic profile and activity of this regimen in previously untreated patients deserves further exploration for the treatment of 5-FU-sensitive tumours." @default.
• W2054652476 created "2016-06-24" @default.
• W2054652476 creator A5001455665 @default.
• W2054652476 creator A5013077987 @default.
• W2054652476 creator A5025381371 @default.
• W2054652476 creator A5031014319 @default.
• W2054652476 creator A5039867262 @default.
• W2054652476 creator A5040179829 @default.
• W2054652476 creator A5043954889 @default.
• W2054652476 creator A5060428508 @default.
• W2054652476 creator A5060714820 @default.
• W2054652476 creator A5078259466 @default.
• W2054652476 creator A5080144386 @default.
• W2054652476 date "1997-09-01" @default.
• W2054652476 modified "2023-09-27" @default.
• W2054652476 title "A phase I trial of 5-day chronomodulated infusion of 5-fluorouracil and 1-folinic acid in patients with metastatic colorectal cancer" @default.
• W2054652476 cites W1902766545 @default.
• W2054652476 cites W1956462378 @default.
• W2054652476 cites W1981794048 @default.
• W2054652476 cites W1996167718 @default.
• W2054652476 cites W2021324583 @default.
• W2054652476 cites W2021919183 @default.
• W2054652476 cites W2043501237 @default.
• W2054652476 cites W2046506020 @default.
• W2054652476 cites W2051142042 @default.
• W2054652476 cites W2057287967 @default.
• W2054652476 cites W2059234543 @default.
• W2054652476 cites W2063820370 @default.
• W2054652476 cites W2065982243 @default.
• W2054652476 cites W2069494887 @default.
• W2054652476 cites W2117500868 @default.
• W2054652476 cites W2167805334 @default.
• W2054652476 cites W2222979086 @default.
• W2054652476 cites W2229860171 @default.
• W2054652476 cites W2247895695 @default.
• W2054652476 cites W2602544133 @default.
• W2054652476 cites W265117922 @default.
• W2054652476 doi "https://doi.org/10.1016/s0959-8049(97)00133-0" @default.
• W2054652476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9389916" @default.
• W2054652476 hasPublicationYear "1997" @default.
• W2054652476 type Work @default.
• W2054652476 sameAs 2054652476 @default.
• W2054652476 citedByCount "25" @default.
• W2054652476 countsByYear W20546524762012 @default.
• W2054652476 countsByYear W20546524762014 @default.
• W2054652476 countsByYear W20546524762015 @default.
• W2054652476 crossrefType "journal-article" @default.
• W2054652476 hasAuthorship W2054652476A5001455665 @default.
• W2054652476 hasAuthorship W2054652476A5013077987 @default.
• W2054652476 hasAuthorship W2054652476A5025381371 @default.
• W2054652476 hasAuthorship W2054652476A5031014319 @default.
• W2054652476 hasAuthorship W2054652476A5039867262 @default.
• W2054652476 hasAuthorship W2054652476A5040179829 @default.
• W2054652476 hasAuthorship W2054652476A5043954889 @default.
• W2054652476 hasAuthorship W2054652476A5060428508 @default.
• W2054652476 hasAuthorship W2054652476A5060714820 @default.
• W2054652476 hasAuthorship W2054652476A5078259466 @default.
• W2054652476 hasAuthorship W2054652476A5080144386 @default.
• W2054652476 hasConcept C121608353 @default.
• W2054652476 hasConcept C126322002 @default.
• W2054652476 hasConcept C141071460 @default.
• W2054652476 hasConcept C2776694085 @default.
• W2054652476 hasConcept C2779051857 @default.
• W2054652476 hasConcept C2779804826 @default.
• W2054652476 hasConcept C2780456651 @default.
• W2054652476 hasConcept C29730261 @default.
• W2054652476 hasConcept C35785553 @default.
• W2054652476 hasConcept C526805850 @default.
• W2054652476 hasConcept C71924100 @default.
• W2054652476 hasConcept C72563966 @default.
• W2054652476 hasConcept C90924648 @default.
• W2054652476 hasConceptScore W2054652476C121608353 @default.
• W2054652476 hasConceptScore W2054652476C126322002 @default.
• W2054652476 hasConceptScore W2054652476C141071460 @default.
• W2054652476 hasConceptScore W2054652476C2776694085 @default.
• W2054652476 hasConceptScore W2054652476C2779051857 @default.
• W2054652476 hasConceptScore W2054652476C2779804826 @default.
• W2054652476 hasConceptScore W2054652476C2780456651 @default.
• W2054652476 hasConceptScore W2054652476C29730261 @default.
• W2054652476 hasConceptScore W2054652476C35785553 @default.
• W2054652476 hasConceptScore W2054652476C526805850 @default.
• W2054652476 hasConceptScore W2054652476C71924100 @default.
• W2054652476 hasConceptScore W2054652476C72563966 @default.
• W2054652476 hasConceptScore W2054652476C90924648 @default.
• W2054652476 hasIssue "10" @default.
• W2054652476 hasLocation W20546524761 @default.
• W2054652476 hasLocation W20546524762 @default.
• W2054652476 hasOpenAccess W2054652476 @default.
• W2054652476 hasPrimaryLocation W20546524761 @default.
• W2054652476 hasRelatedWork W1981794048 @default.
• W2054652476 hasRelatedWork W2012864969 @default.
• W2054652476 hasRelatedWork W2031477213 @default.
• W2054652476 hasRelatedWork W2033860338 @default.
• W2054652476 hasRelatedWork W2040894732 @default.
• W2054652476 hasRelatedWork W2072252734 @default.
• W2054652476 hasRelatedWork W2289397400 @default.
• W2054652476 hasRelatedWork W2364607478 @default.
• W2054652476 hasRelatedWork W2444073517 @default.

• next