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- W2054653463 abstract "Moderate hypothermia is consistently neuroprotective after hypoxic-ischemic insults and is the subject of ongoing clinical trials. In pilot studies, we observed rebound seizure activity in one infant during rewarming from a 72-h period of hypothermia. We therefore quantified the development of EEG-defined seizures during rewarming in an experimental paradigm of delayed cooling for cerebral ischemia. Moderate cerebral hypothermia (n = 9) or sham cooling (n = 13) was initiated 5.5 h after reperfusion from a 30-min period of bilateral carotid occlusion in near-term fetal sheep and continued for 72 h after the insult. During spontaneous rewarming, fetal extradural temperature rose from 32.5 ± 0.6°C to control levels (39.4 ± 0.1°C) in 47 ± 6 min. Carotid blood flow and mean arterial blood pressure increased transiently during rewarming. The cooling group showed a significant increase in electrical seizure events 2, 3, and 5 h after rewarming, maximal at 2 h (2.9 ± 1.2 versus 0.5 ± 0.5 events/h; p < 0.05). From 6 h after rewarming, there was no significant difference between the groups. Individual seizures were typically short (28.8 ± 5.8 s versus 29.0 ± 6.8 s in sham cooled; NS), and of modest amplitude (35.9 ± 2.8 versus 38.8 ± 3.4 μV; NS). Neuronal loss in the parasagittal cortex was significantly reduced in the cooled group (51 ± 9% versus 91 ± 5%; p < 0.002) and was not correlated with rebound epileptiform activity. In conclusion, rapid rewarming after a prolonged interval of therapeutic hypothermia can be associated with a transient increase in epileptiform events but does not seem to have significant adverse implications for neural outcome." @default.
- W2054653463 created "2016-06-24" @default.
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- W2054653463 date "2005-03-01" @default.
- W2054653463 modified "2023-10-17" @default.
- W2054653463 title "Epileptiform Activity During Rewarming from Moderate Cerebral Hypothermia in the Near-Term Fetal Sheep" @default.
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- W2054653463 doi "https://doi.org/10.1203/01.pdr.0000150801.61188.5f" @default.
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