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• W2054653907 abstract "The myogenic enhancer factor 2 (Mef2) transcription factors are known for their role in the control of cardiac development. Here we describe the spatial and temporal expression patterns of five Atlantic cod mef2 genes designated as mef2a, mef2cI, mef2cII, mef2dI and mef2dII during cardiogenesis. Whole mount in situ hybridization showed that mef2a and mef2dI were expressed in both cardiac ring and cone prior to looping morphogenesis, while mef2dII expression was only detectable in the cardiac ring. The mef2cI and mef2cII paralogs displayed different spatial expression patterns in the heart tube with a venous and arterial pole preference, respectively. After the cardiac loop formation mef2cI was expressed in cells of the ventricle and lateral arteries, while mef2cII appeared more abundant and was also present in the atrium. Larvae raised at constant 8 °C showed malformed morphology of the lateral arteries, and the transcription of both mef2c variants was highly elevated compared to those kept at 4 °C. Acute temperature stress also resulted in deviations in the expression of the mef2c paralogs, and the treated embryos displayed defects in the developing heart, including impaired fusion of the bilateral primordia and truncated heart tubes." @default.
• W2054653907 created "2016-06-24" @default.
• W2054653907 creator A5030956640 @default.
• W2054653907 creator A5045358100 @default.
• W2054653907 creator A5046794253 @default.
• W2054653907 date "2011-02-01" @default.
• W2054653907 modified "2023-09-23" @default.
• W2054653907 title "Differential spatial expression of mef2 paralogs during cardiac development in Atlantic cod (Gadus morhua)" @default.
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• W2054653907 doi "https://doi.org/10.1016/j.cbpb.2010.11.006" @default.
• W2054653907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21109015" @default.
• W2054653907 hasPublicationYear "2011" @default.
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