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• W2054654316 abstract "Background: Steroid‐based, non‐depolarizing neuromuscular‐blocking (NMB) drugs (e.g. rocuronium, vecuronium) are characterized by organ‐dependent elimination and significantly longer durations of action in elderly compared to young patients. Cisatracurium is a benzylisoquinolinium NMB drug with a duration of action not altered by ageing. The objective of the study was to determine if elderly patients had less variability in duration of action with 2 × ED95 of cisatracurium compared to equipotent doses of rocuronium or vecuronium. Methods: Informed consent was obtained from 66 elderly patients with normal renal and liver function. Preoperative midazolam (1 mg) was given IV. The anaesthestic induction was with 5 mg kg −1 thiopental and 2 µg kg −1 fentanyl. The patients received 0.6 mg kg −1 rocuronium, 0.1 mg kg −1 vecuronium or 0.1 mg kg −1 cisatracurium. Anaesthetic maintenance was with sevoflurane in oxygen/nitrous oxide. Neuromuscular‐blocking duration of action was defined as the return of T1 twitch height to 25% of control. Variability was determined by subtracting the actual duration of action from the mean duration of action for each drug. Results: The durations of action (range, min) were: cisatracurium, 37–81; vecuronium, 35–137; and rocuronium, 33–119. The median of the variability of duration was significantly less with cisatracurium (7 min) compared to vecuronium (18 min) and rocuronium (18 min) ( P < 0.05). Conclusion: When used with sevoflurane/N 2 O, there was a two‐fold greater variability of duration of neuromuscular blockade in elderly patients receiving rocuronium or vecuronium compared with cisatracurium." @default.
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• W2054654316 date "2005-03-01" @default.
• W2054654316 modified "2023-10-10" @default.
• W2054654316 title "Variability of duration of action of neuromuscular-blocking drugs in elderly patients" @default.
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• W2054654316 doi "https://doi.org/10.1111/j.1399-6576.2005.00634.x" @default.
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