FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054663177> ?p ?o ?g. }

• W2054663177 endingPage "209" @default.
• W2054663177 startingPage "203" @default.
• W2054663177 abstract "Nitric oxide (NO) is a biologically important short-lived free radical signaling molecule. Both the enzymatic synthesis and the predominant forms of cellular metabolism of NO are oxygen-dependent. For these reasons, changes in local oxygen concentrations can have a profound influence on steady-state NO concentrations. Many proteins are regulated by NO in a concentration-dependent manner, but their responses are elicited at different thresholds. Using soluble guanylyl cyclase (sGC) and p53 as model NO-sensitive proteins, we demonstrate that their concentration-dependent responses to NO are a function of the O2 concentration. p53 requires relatively high steady-state NO concentrations (>600 nM) to induce its phosphorylation (P-ser-15), whereas sGC responds to low NO concentrations (<100 nM). At a constant rate of NO production (liberation from NO-donors), decreasing the O2 concentration (1%) lowers the rate of NO metabolism. This raises steady-state NO concentrations and allows p53 activation at lower doses of the NO donor. Enzymatic NO production, however, requires O2 as a substrate such that decreasing the O2 concentration below the Km for O2 for nitric oxide synthase (NOS) will decrease the production of NO. We demonstrate that the amount of NO produced by RAW 264.7 macrophages is a function of the O2 concentration. Differences in rates of NO production and NO metabolism result in differential sGC activation that is not linear with respect to O2. There is an optimal O2 concentration (≈5–8%) where a balance between the synthesis and metabolism of NO is established such that both the NO concentration and sGC activation are maximal." @default.
• W2054663177 created "2016-06-24" @default.
• W2054663177 creator A5036481310 @default.
• W2054663177 creator A5040870196 @default.
• W2054663177 creator A5056553446 @default.
• W2054663177 creator A5068239896 @default.
• W2054663177 date "2013-01-01" @default.
• W2054663177 modified "2023-10-17" @default.
• W2054663177 title "Oxygen dependence of nitric oxide-mediated signaling" @default.
• W2054663177 cites W1509518731 @default.
• W2054663177 cites W1980458823 @default.
• W2054663177 cites W2002575458 @default.
• W2054663177 cites W2026623916 @default.
• W2054663177 cites W2058062846 @default.
• W2054663177 cites W2069432717 @default.
• W2054663177 cites W2073983985 @default.
• W2054663177 cites W2085719171 @default.
• W2054663177 cites W2090462077 @default.
• W2054663177 doi "https://doi.org/10.1016/j.redox.2012.11.002" @default.
• W2054663177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3757674" @default.
• W2054663177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24024154" @default.
• W2054663177 hasPublicationYear "2013" @default.
• W2054663177 type Work @default.
• W2054663177 sameAs 2054663177 @default.
• W2054663177 citedByCount "37" @default.
• W2054663177 countsByYear W20546631772013 @default.
• W2054663177 countsByYear W20546631772014 @default.
• W2054663177 countsByYear W20546631772015 @default.
• W2054663177 countsByYear W20546631772016 @default.
• W2054663177 countsByYear W20546631772017 @default.
• W2054663177 countsByYear W20546631772018 @default.
• W2054663177 countsByYear W20546631772019 @default.
• W2054663177 countsByYear W20546631772020 @default.
• W2054663177 countsByYear W20546631772021 @default.
• W2054663177 countsByYear W20546631772022 @default.
• W2054663177 countsByYear W20546631772023 @default.
• W2054663177 crossrefType "journal-article" @default.
• W2054663177 hasAuthorship W2054663177A5036481310 @default.
• W2054663177 hasAuthorship W2054663177A5040870196 @default.
• W2054663177 hasAuthorship W2054663177A5056553446 @default.
• W2054663177 hasAuthorship W2054663177A5068239896 @default.
• W2054663177 hasBestOaLocation W20546631771 @default.
• W2054663177 hasConcept C11960822 @default.
• W2054663177 hasConcept C121332964 @default.
• W2054663177 hasConcept C12554922 @default.
• W2054663177 hasConcept C147789679 @default.
• W2054663177 hasConcept C148898269 @default.
• W2054663177 hasConcept C150555746 @default.
• W2054663177 hasConcept C173803235 @default.
• W2054663177 hasConcept C178790620 @default.
• W2054663177 hasConcept C181199279 @default.
• W2054663177 hasConcept C185592680 @default.
• W2054663177 hasConcept C18903297 @default.
• W2054663177 hasConcept C2777289219 @default.
• W2054663177 hasConcept C2777622882 @default.
• W2054663177 hasConcept C2778827303 @default.
• W2054663177 hasConcept C519581460 @default.
• W2054663177 hasConcept C540031477 @default.
• W2054663177 hasConcept C55493867 @default.
• W2054663177 hasConcept C62231903 @default.
• W2054663177 hasConcept C62478195 @default.
• W2054663177 hasConcept C62520636 @default.
• W2054663177 hasConcept C8171440 @default.
• W2054663177 hasConcept C86803240 @default.
• W2054663177 hasConcept C89169090 @default.
• W2054663177 hasConceptScore W2054663177C11960822 @default.
• W2054663177 hasConceptScore W2054663177C121332964 @default.
• W2054663177 hasConceptScore W2054663177C12554922 @default.
• W2054663177 hasConceptScore W2054663177C147789679 @default.
• W2054663177 hasConceptScore W2054663177C148898269 @default.
• W2054663177 hasConceptScore W2054663177C150555746 @default.
• W2054663177 hasConceptScore W2054663177C173803235 @default.
• W2054663177 hasConceptScore W2054663177C178790620 @default.
• W2054663177 hasConceptScore W2054663177C181199279 @default.
• W2054663177 hasConceptScore W2054663177C185592680 @default.
• W2054663177 hasConceptScore W2054663177C18903297 @default.
• W2054663177 hasConceptScore W2054663177C2777289219 @default.
• W2054663177 hasConceptScore W2054663177C2777622882 @default.
• W2054663177 hasConceptScore W2054663177C2778827303 @default.
• W2054663177 hasConceptScore W2054663177C519581460 @default.
• W2054663177 hasConceptScore W2054663177C540031477 @default.
• W2054663177 hasConceptScore W2054663177C55493867 @default.
• W2054663177 hasConceptScore W2054663177C62231903 @default.
• W2054663177 hasConceptScore W2054663177C62478195 @default.
• W2054663177 hasConceptScore W2054663177C62520636 @default.
• W2054663177 hasConceptScore W2054663177C8171440 @default.
• W2054663177 hasConceptScore W2054663177C86803240 @default.
• W2054663177 hasConceptScore W2054663177C89169090 @default.
• W2054663177 hasIssue "1" @default.
• W2054663177 hasLocation W20546631771 @default.
• W2054663177 hasLocation W20546631772 @default.
• W2054663177 hasLocation W20546631773 @default.
• W2054663177 hasLocation W20546631774 @default.
• W2054663177 hasOpenAccess W2054663177 @default.
• W2054663177 hasPrimaryLocation W20546631771 @default.
• W2054663177 hasRelatedWork W1530399633 @default.
• W2054663177 hasRelatedWork W1966928669 @default.
• W2054663177 hasRelatedWork W1970659243 @default.

• next