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• W2054665953 startingPage "227" @default.
• W2054665953 abstract "New generations of cyclooxygenase (COX) inhibitors are more potent and efficacious than their traditional parent compounds. They are also safer than the classic non-steroidal anti-inflammatory drugs (NSAIDs) and are starting to be used not only for low to moderate intensity pain, but also for high intensity pain. Three different strategies have been followed to improve the pharmacological profile of COX inhibitors: 1. Development of COX-2 selective inhibitors. This is based on the initial hypothesis that considered COX-2 as the enzyme responsible for the generation of prostaglandins only in inflammation, and, therefore, uniquely responsible for inflammation, pain and fever. Initial expectations gave rise to controversial results, still under discussion. The second generation of these compounds is being developed and should contribute to clarifying both their efficacy and the specific functions of the COX enzymes. 2. Modified non-selective COX inhibitors. Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation. Nitroaspirin, nitroparacetamol or dexketoprofen trometamol are some examples of molecules that are already showing an important clinical efficacy. The modifications performed in their structures seem to lower the unwanted side effects as well as to enhance their analgesic efficacy. 3. Combined therapy of classic NSAIDs with other drugs. This strategy looks for improvements in the incidence of adverse effects or to take advantage of the synergistic enhancement of their therapeutic effects. Some of the molecules resulting from these strategies are very valuable as therapeutic agents and open a wide range of possibilities in the treatment of high intensity pain, including neuropathic pain, and opiate sparing therapy." @default.
• W2054665953 created "2016-06-24" @default.
• W2054665953 creator A5012117352 @default.
• W2054665953 creator A5034120338 @default.
• W2054665953 creator A5058571216 @default.
• W2054665953 creator A5089517521 @default.
• W2054665953 date "2006-06-07" @default.
• W2054665953 modified "2023-10-11" @default.
• W2054665953 title "Antinociception and the New COX Inhibitors: Research Approaches and Clinical Perspectives" @default.
• W2054665953 cites W105287088 @default.
• W2054665953 cites W122098455 @default.
• W2054665953 cites W132966847 @default.
• W2054665953 cites W147938445 @default.
• W2054665953 cites W1488935046 @default.
• W2054665953 cites W1506006387 @default.
• W2054665953 cites W1545823900 @default.
• W2054665953 cites W1626809853 @default.
• W2054665953 cites W1646525527 @default.
• W2054665953 cites W1650183152 @default.
• W2054665953 cites W1657319651 @default.
• W2054665953 cites W175209219 @default.
• W2054665953 cites W18740534 @default.
• W2054665953 cites W1906405556 @default.
• W2054665953 cites W1922681024 @default.
• W2054665953 cites W1922693001 @default.
• W2054665953 cites W1965108173 @default.
• W2054665953 cites W1966044567 @default.
• W2054665953 cites W1968483488 @default.
• W2054665953 cites W1968818398 @default.
• W2054665953 cites W1968858542 @default.
• W2054665953 cites W1972016476 @default.
• W2054665953 cites W1977766028 @default.
• W2054665953 cites W1978759500 @default.
• W2054665953 cites W1978896524 @default.
• W2054665953 cites W1978988947 @default.
• W2054665953 cites W1980463403 @default.
• W2054665953 cites W1981662925 @default.
• W2054665953 cites W1982328070 @default.
• W2054665953 cites W1983104516 @default.
• W2054665953 cites W1985198002 @default.
• W2054665953 cites W1985662930 @default.
• W2054665953 cites W1985844039 @default.
• W2054665953 cites W1986619381 @default.
• W2054665953 cites W1987494019 @default.
• W2054665953 cites W1990756964 @default.
• W2054665953 cites W1991519612 @default.
• W2054665953 cites W1991701175 @default.
• W2054665953 cites W1993697980 @default.
• W2054665953 cites W1993881834 @default.
• W2054665953 cites W1994464747 @default.
• W2054665953 cites W1996123177 @default.
• W2054665953 cites W2002068547 @default.
• W2054665953 cites W2004916700 @default.
• W2054665953 cites W2006512496 @default.
• W2054665953 cites W2006635498 @default.
• W2054665953 cites W2008574207 @default.
• W2054665953 cites W2009366638 @default.
• W2054665953 cites W2009724412 @default.
• W2054665953 cites W2010673118 @default.
• W2054665953 cites W2011666006 @default.
• W2054665953 cites W2014371748 @default.
• W2054665953 cites W2014534197 @default.
• W2054665953 cites W2015926018 @default.
• W2054665953 cites W2019564380 @default.
• W2054665953 cites W2021162072 @default.
• W2054665953 cites W2021313793 @default.
• W2054665953 cites W2022317103 @default.
• W2054665953 cites W2024065712 @default.
• W2054665953 cites W2024289681 @default.
• W2054665953 cites W2024608254 @default.
• W2054665953 cites W2031115234 @default.
• W2054665953 cites W2032890959 @default.
• W2054665953 cites W2033498682 @default.
• W2054665953 cites W2034468337 @default.
• W2054665953 cites W2035928774 @default.
• W2054665953 cites W2036320267 @default.
• W2054665953 cites W2036488915 @default.
• W2054665953 cites W2037568430 @default.
• W2054665953 cites W2040040765 @default.
• W2054665953 cites W2040603499 @default.
• W2054665953 cites W2041438513 @default.
• W2054665953 cites W2045886062 @default.
• W2054665953 cites W2049481868 @default.
• W2054665953 cites W2051318074 @default.
• W2054665953 cites W2051792722 @default.
• W2054665953 cites W2056985247 @default.
• W2054665953 cites W2057573581 @default.
• W2054665953 cites W2057727574 @default.
• W2054665953 cites W2061188274 @default.
• W2054665953 cites W2061317152 @default.
• W2054665953 cites W2062109461 @default.
• W2054665953 cites W2063842505 @default.
• W2054665953 cites W2065743017 @default.
• W2054665953 cites W2068523715 @default.
• W2054665953 cites W2073374878 @default.
• W2054665953 cites W2075121194 @default.
• W2054665953 cites W2075476097 @default.
• W2054665953 cites W2077502100 @default.

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