FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054674774> ?p ?o ?g. }

• W2054674774 endingPage "529" @default.
• W2054674774 startingPage "517" @default.
• W2054674774 abstract "The current classification of human sporadic prion diseases recognizes six major phenotypic subtypes with distinctive clinicopathological features, which largely correlate at the molecular level with the genotype at the polymorphic codon 129 (methionine, M, or valine, V) in the prion protein gene and with the size of the protease-resistant core of the abnormal prion protein, PrPSc (i.e. type 1 migrating at 21 kDa and type 2 at 19 kDa). We previously demonstrated that PrPSc typing by Western blotting is a reliable means of strain typing and disease classification. Limitations of this approach, however, particularly in the interlaboratory setting, are the association of PrPSc types 1 or 2 with more than one clinicopathological phenotype, which precludes definitive case classification if not supported by further analysis, and the difficulty of fully recognizing cases with mixed phenotypic features. In this study, we tested the inter-rater reliability of disease classification based only on histopathological criteria. Slides from 21 cases covering the whole phenotypic spectrum of human sporadic prion diseases, and also including two cases of variant Creutzfeldt–Jakob disease (CJD), were distributed blindly to 13 assessors for classification according to given instructions. The results showed good-to-excellent agreement between assessors in the classification of cases. In particular, there was full agreement (100 %) for the two most common sporadic CJD subtypes and variant CJD, and very high concordance in general for all pure phenotypes and the most common subtype with mixed phenotypic features. The present data fully support the basis for the current classification of sporadic human prion diseases and indicate that, besides molecular PrPSc typing, histopathological analysis permits reliable disease classification with high interlaboratory accuracy." @default.
• W2054674774 created "2016-06-24" @default.
• W2054674774 creator A5001416778 @default.
• W2054674774 creator A5002436634 @default.
• W2054674774 creator A5004166000 @default.
• W2054674774 creator A5009231408 @default.
• W2054674774 creator A5012158059 @default.
• W2054674774 creator A5012358602 @default.
• W2054674774 creator A5012669917 @default.
• W2054674774 creator A5014287588 @default.
• W2054674774 creator A5021873304 @default.
• W2054674774 creator A5022260481 @default.
• W2054674774 creator A5023875722 @default.
• W2054674774 creator A5025292977 @default.
• W2054674774 creator A5036667862 @default.
• W2054674774 creator A5039614344 @default.
• W2054674774 creator A5047812313 @default.
• W2054674774 creator A5062781311 @default.
• W2054674774 creator A5075292117 @default.
• W2054674774 creator A5089628831 @default.
• W2054674774 date "2012-06-30" @default.
• W2054674774 modified "2023-10-16" @default.
• W2054674774 title "Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA" @default.
• W2054674774 cites W1557724928 @default.
• W2054674774 cites W1624018543 @default.
• W2054674774 cites W1909091101 @default.
• W2054674774 cites W1971168935 @default.
• W2054674774 cites W1999806672 @default.
• W2054674774 cites W2004333317 @default.
• W2054674774 cites W2010995383 @default.
• W2054674774 cites W2018594556 @default.
• W2054674774 cites W2021417572 @default.
• W2054674774 cites W2022614447 @default.
• W2054674774 cites W2028245937 @default.
• W2054674774 cites W2028491819 @default.
• W2054674774 cites W2033638305 @default.
• W2054674774 cites W2036078080 @default.
• W2054674774 cites W2037565795 @default.
• W2054674774 cites W2037605535 @default.
• W2054674774 cites W2041939047 @default.
• W2054674774 cites W2042118417 @default.
• W2054674774 cites W2050519825 @default.
• W2054674774 cites W2056426612 @default.
• W2054674774 cites W2058032460 @default.
• W2054674774 cites W2058148369 @default.
• W2054674774 cites W2064722614 @default.
• W2054674774 cites W2064898026 @default.
• W2054674774 cites W2082573664 @default.
• W2054674774 cites W2083851817 @default.
• W2054674774 cites W2089141965 @default.
• W2054674774 cites W2089215677 @default.
• W2054674774 cites W2089569305 @default.
• W2054674774 cites W2092556927 @default.
• W2054674774 cites W2103146711 @default.
• W2054674774 cites W2112683645 @default.
• W2054674774 cites W2128228199 @default.
• W2054674774 cites W2135120391 @default.
• W2054674774 cites W2137802088 @default.
• W2054674774 cites W2149813545 @default.
• W2054674774 cites W2168968213 @default.
• W2054674774 cites W2170314199 @default.
• W2054674774 cites W2324660492 @default.
• W2054674774 doi "https://doi.org/10.1007/s00401-012-1002-8" @default.
• W2054674774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3725314" @default.
• W2054674774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22744790" @default.
• W2054674774 hasPublicationYear "2012" @default.
• W2054674774 type Work @default.
• W2054674774 sameAs 2054674774 @default.
• W2054674774 citedByCount "173" @default.
• W2054674774 countsByYear W20546747742013 @default.
• W2054674774 countsByYear W20546747742014 @default.
• W2054674774 countsByYear W20546747742015 @default.
• W2054674774 countsByYear W20546747742016 @default.
• W2054674774 countsByYear W20546747742017 @default.
• W2054674774 countsByYear W20546747742018 @default.
• W2054674774 countsByYear W20546747742019 @default.
• W2054674774 countsByYear W20546747742020 @default.
• W2054674774 countsByYear W20546747742021 @default.
• W2054674774 countsByYear W20546747742022 @default.
• W2054674774 countsByYear W20546747742023 @default.
• W2054674774 crossrefType "journal-article" @default.
• W2054674774 hasAuthorship W2054674774A5001416778 @default.
• W2054674774 hasAuthorship W2054674774A5002436634 @default.
• W2054674774 hasAuthorship W2054674774A5004166000 @default.
• W2054674774 hasAuthorship W2054674774A5009231408 @default.
• W2054674774 hasAuthorship W2054674774A5012158059 @default.
• W2054674774 hasAuthorship W2054674774A5012358602 @default.
• W2054674774 hasAuthorship W2054674774A5012669917 @default.
• W2054674774 hasAuthorship W2054674774A5014287588 @default.
• W2054674774 hasAuthorship W2054674774A5021873304 @default.
• W2054674774 hasAuthorship W2054674774A5022260481 @default.
• W2054674774 hasAuthorship W2054674774A5023875722 @default.
• W2054674774 hasAuthorship W2054674774A5025292977 @default.
• W2054674774 hasAuthorship W2054674774A5036667862 @default.
• W2054674774 hasAuthorship W2054674774A5039614344 @default.
• W2054674774 hasAuthorship W2054674774A5047812313 @default.
• W2054674774 hasAuthorship W2054674774A5062781311 @default.
• W2054674774 hasAuthorship W2054674774A5075292117 @default.

• next